In-vitro activity of DU-6859a against methicillin-resistant Staphylococcus aureus isolates with reduced susceptibilities to vancomycin.
In-vitro activity of DU-6859a against methicillin-resistant Staphylococcus aureus isolates with reduced susceptibilities to vancomycin.
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DU-6859a 对万古霉素敏感性降低的耐甲氧西林金黄色葡萄球菌分离株的体外活性。
DOI：
10.1093/jac/42.4.552
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
K. Hiramatsu
中科院分区：
文献类型：
--
作者：
M. Tanaka;N. Wada;S. Kurosaka;M. Chiba;K. Sato;K. Hiramatsu
金黄色葡萄球菌菌株，对万古霉素的敏感性降低本研究旨在评价DU-6859 a（一种新型研究性喹诺酮）对VISA菌株及其假定前体菌株（异源VISA）及其体外衍生物Mu 3 - 8 R的体外活性，Mu 3 - 8 R是在含有浓度为8 mg/L万古霉素的琼脂上对Mu 3进行单次传代后选择的。我们还确定了核苷酸序列的喹诺酮耐药决定区（QRDRs）的基因编码的II型拓扑异构酶在这些菌株。
strain of Staphylococcus aureus , reduced susceptibility to vancomycin The present was to evaluate the in-vitro activity of DU-6859a, a novel investi-gative quinolone, against VISA strain its pre-sumptive precursor strain (hetero-VISA) and its in-vitro derivative, Mu3-8R, which was selected following single passage of Mu3 on agar containing vancomycin at a concentration of 8 mg/L. We also determined the nucleo-tide sequences of the quinolone-resistance determining regions (QRDRs) of the genes encoding type II topo-isomerases in these strains.