Growth delay as an index of allostatic load in young children: predictions to disinhibited social approach and diurnal cortisol activity.
Growth delay as an index of allostatic load in young children: predictions to disinhibited social approach and diurnal cortisol activity.
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DOI：
10.1017/s0954579411000356
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发表时间：
2011-08
影响因子：
3.3
通讯作者：
Gunnar MR
中科院分区：
文献类型：
--
作者：
Johnson AE;Bruce J;Tarullo AR;Gunnar MR
本研究的目的是检查生长延迟是否可以作为早期发育过程中的非稳态负荷的指标，因为众所周知，应激介导系统的活性抑制生长。参与者是国际收养的儿童从机构照顾（n = 36），国际收养的儿童从寄养（n = 6），和nonadopted儿童（n = 35）。对于被收养的儿童，在收养时评估了年龄别身高和身高别体重;对于所有儿童，在6-8岁（M = 6.9岁）时评估了无抑制的社交方式（DSA;在其他地方称为“不分青红皂白的友好”）和昼夜皮质醇。对于一般的国际收养儿童，特别是机构化后的儿童，在收养时评估的线性生长延迟与应对不熟悉的成年人的更多失调行为有关（即，更大的DSA）和更失调的昼夜皮质醇节律（即，下午和晚上的值更高）。此外，在生长延迟最严重的儿童中，当天晚些时候较高的皮质醇水平与DSA相关。使用生长延迟作为一个非稳态负荷指标和可能的问题和限制，在儿童人群中使用的潜力进行了讨论。
The goal of this study was to examine whether growth delay can serve as an index of allostatic load during early development, as it is well known that the activity of stress-mediating systems inhibits growth. The participants were children adopted internationally from institutional care (n = 36), children adopted internationally from foster care (n = 6), and nonadopted children (n = 35). For the adopted children, height-for-age and weight-for-height were assessed at adoption; for all children, disinhibited social approach (DSA; termed elsewhere as “indiscriminate friendliness”) and diurnal cortisol were assessed at 6–8 years (M = 6.9 years). For internationally adopted children in general, and postinstitutionalized children specifically, linear growth delay assessed at the time of adoption was associated with more dysregulated behavior in response to an unfamiliar adult (i.e., greater DSA) and a more dysregulated diurnal cortisol rhythm (i.e., higher late-afternoon and evening values). Further, among the most growth-delayed children, higher cortisol levels later in the day were correlated with DSA. The potential for using growth delay as an allostatic load indicator and the possible problems and limitations in its use in child populations are discussed.