A new coronavirus associated with human respiratory disease in China
A new coronavirus associated with human respiratory disease in China
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DOI：
10.1038/s41586-020-2008-3
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发表时间：
2020-02-03
期刊：
影响因子：
64.8
通讯作者：
Zhang, Yong-Zhen
中科院分区：
文献类型：
--
作者：
Wu, Fan;Zhao, Su;Zhang, Yong-Zhen
严重急性呼吸系统综合症 (SARS) 和寨卡病毒病等新出现的传染病对公众健康构成重大威胁(1-3)。尽管进行了大量的研究工作，但新疾病如何、何时、何地出现仍然存在相当大的不确定性。中国湖北省武汉市最近报告了严重的呼吸道疾病。自2019年12月12日第一例患者住院以来，截至2020年1月25日，至少报告了1,975例病例。流行病学调查表明，此次疫情与武汉的一个海鲜市场有关。我们在这里研究了一名市场工人的患者，他于 2019 年 12 月 26 日被武汉市中心医院收治，当时患有严重的呼吸道综合症，包括发烧、头晕和咳嗽。对患者支气管肺泡灌洗液样本进行宏基因组 RNA 测序(4)，鉴定出一种来自冠状病毒科的新 RNA 病毒株，此处将其命名为“WH-人类 1”冠状病毒（也称为“2019-nCoV”）。对完整病毒基因组（29,903 个核苷酸）的系统发育分析表明，该病毒与之前在中国蝙蝠中发现的一组 SARS 样冠状病毒（β 冠状病毒属，Sarbecovirus 亚属）关系最密切（89.1% 核苷酸相似性）(5)。此次疫情凸显了病毒从动物中溢出并在人类中引起严重疾病的持续能力。对冠状病毒科新型冠状病毒完整病毒基因组的系统发育和宏基因组分析表明，该病毒与在中国蝙蝠中发现的一组类似 SARS 的冠状病毒密切相关。
Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health(1-3). Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing(4) of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China(5). This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.