Autism is characterized by dorsal anterior cingulate hyperactivation during social target detection
Autism is characterized by dorsal anterior cingulate hyperactivation during social target detection
复制标题
DOI：
10.1093/scan/nsp017
复制
发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Bodfish, James W.
中科院分区：
文献类型：
--
作者：
Dichter, Gabriel S.;Felder, Jennifer N.;Bodfish, James W.
虽然自闭症谱系障碍（ASD）中认知控制受损和社会功能障碍的功能性神经关联已被描述，但涉及社会信息认知控制不良的大脑区域是自闭症研究的一个新领域。我们最近在一个非临床样本中报告称，对“社会异类”目标的检测激活了背侧前扣带回 gyrus的一部分以及距状沟上皮质（迪希特、费尔德、博德菲什、西基奇和贝尔格，2009年）。在本次研究中，我们报告了完成相同社会异类任务的自闭症患者的功能性磁共振成像结果。组间比较显示，自闭症组对社会和非社会目标的激活普遍更强。当对比对社会和非社会目标的反应时，自闭症组在右侧和中间额下回以及背内侧前额叶皮质中与背侧前扣带回相邻的一个区域（布罗德曼32区）显示出相对更强的激活。此外，背侧前扣带回对社会目标的激活预测了自闭症样本的一个子集中社会障碍的严重程度。这些数据表明，背侧前扣带回在神经正常个体中调节社会目标检测，并与自闭症中社会信息认知控制的缺陷有关。
Though the functional neural correlates of impaired cognitive control and social dysfunction in autism spectrum disorders (ASD) have been delineated, brain regions implicated in poor cognitive control of social information is a novel area of autism research. We recently reported in a non-clinical sample that detection of 'social oddball' targets activated a portion of the dorsal anterior cingulate gyrus and the supracalcarine cortex (Dichter, Felder, Bodfish, Sikich, and Belger, 2009). In the present investigation, we report functional magnetic resonance imaging results from individuals with ASD who completed the same social oddball task. Between-group comparisons revealed generally greater activation in the ASD group to both social and non-social targets. When responses to social and non-social targets were contrasted, the ASD group showed relatively greater activation in the right and middle inferior frontal gyri and a region in dorsomedial prefrontal cortex that abuts the dorsal anterior cingulate (Brodmann's Area 32). Further, dorsal anterior cingulate activation to social targets predicted the severity of social impairments in a subset of the ASD sample. These data suggest that the dorsal anterior cingulate mediates social target detection in neurotypical individuals and is implicated in deficits of cognitive control of social information in ASD.