Small noncleaved, non-Burkitt's (Burkitt-like) lymphoma: Cytogenetics predict outcome and reflect clinical presentation
Small noncleaved, non-Burkitt's (Burkitt-like) lymphoma: Cytogenetics predict outcome and reflect clinical presentation
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DOI：
10.1200/jco.1999.17.5.1558
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发表时间：
1999-05-01
影响因子：
45.3
通讯作者：
Gascoyne, RD
中科院分区：
文献类型：
--
作者：
Macpherson, N;Lesack, D;Gascoyne, RD
目的：探讨细胞遗传学异常与Burkitt样小型无裂样NaN-Burkitt淋巴瘤(SNC-NB)临床表现和预后的关系。方法：对~1996年1月间收治的39例具有克隆性核型的SNC-NB患者进行分析，所有患者均来自加拿大不列颠哥伦比亚省，均接受统一的临床分期，少数临床医生按研究方案进行治疗。(2)c-myc和bcl2双易位(n=13)；(3)有其他细胞遗传学异常的患者(n=15)，c-myc组年龄较小，有较早的新生疾病，临床预后因素较好，双易位和其他组年龄较大，且处于晚期，预后较差，双易位组中有较大比例的患者已从先前诊断的滤泡性淋巴瘤转化，所有患者的中位总生存期(OS)均为5个月，双易位组的中位OS时间仅为2.5个月，而c-myc组和其他组分别为7个月和8个月(P
Purpose: To correlate cytogenetic abnormalities with clinical presentation and outcome in Burkitt-like, small noncleaved nan-Burkitt's lymphoma (SNC-NB),Patients and Methods: Thirty-nine patients with SNC-NB lymphoma and a clonal karyotype were evaluated between January 1989 and January 1996, All were from British Columbia, Canada, underwent uniform clinical staging, and were treated on investigational protocols by a small group of clinicians.Results: Three groups of patients were identified by clonal karyotype on cytogenetic analysis: (1)those with a c-myc translocation (n = 11); (2) those with dual translocation of c-myc and bcl-2 (n = 13); and (3) those with other cytogenetic abnormalities (n = 15), The c-myc group was younger, presented with earlier stage de novo disease, and had a better clinical prognostic factor profile, The dual-translocation and other groups were older and presented in advanced stage with poorer prognostic features, and a larger proportion of the dual-translocation group patients had transformed from previously diagnosed follicular lymphoma, The median overall survival (OS) time for all patients wets 5 months, The median OS time for the dual-translocation group was only 2.5 months, as compared with 7 months and 8 months for the c-myc and other group, respectively (P