The molecular biology of hepatitis B virus.
The molecular biology of hepatitis B virus.
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DOI：
10.1016/0168-9525(89)90057-7
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
H. Blum;H. Blum;H. Blum;Wolfgang Gerok;Wolfgang Gerok;Wolfgang Gerok;G. Vyas;Girish N. Vyas-Girish-N.-Vya
中科院分区：
文献类型：
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作者：
H. Blum;H. Blum;H. Blum;Wolfgang Gerok;Wolfgang Gerok;Wolfgang Gerok;G. Vyas;Girish N. Vyas-Girish-N.-Vya
在受感染的个体中，HBV以三种形态学上不同的形式存在：直径约22 nm的球体，直径相同且长度高达数百nm的丝状颗粒，以及称为Dane颗粒的更复杂的结构。球形和丝状都代表不完整的病毒颗粒，而Dane颗粒被认为是B型肝炎病毒粒子。B型肝炎病毒粒子（图1）由电子致密的内部核心结构（核衣壳）和包膜组成。包膜由B型肝炎表面抗原（HBsAg）组成，其与上述不完整病毒颗粒共享抗原决定簇。三种主要血清型
In infected individuals, HBV is found in three morphologically distinct forms: as spheres of about 22 nm diameter, as filamentous particles of the same diameter and up to several hundred nm in length and as more complex structures known as Dane particles. The spheres and filaments both represent incomplete viral particles, while the Dane particles are considered to be the hepatitis B virion.The hepatitis B virion (Fig. 1) consists of an electron-dense internal core structure (the nucleocapsid) and an envelope. The envelope is made up of the hepatitis B surface antigens (HBsAgs) which share antigenic determinants with the incomplete viral particles mentioned above. Three main serotypes of