The mouse ascending: perspectives for human-disease models
The mouse ascending: perspectives for human-disease models
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DOI：
10.1038/ncb437
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发表时间：
2007-09-01
影响因子：
21.3
通讯作者：
Brown, Steve
中科院分区：
文献类型：
--
作者：
Rosenthal, Nadia;Brown, Steve
实验室小鼠被广泛认为是研究人类疾病的首选模式生物，它们与人类分享99%的基因。随着操纵小鼠基因组的强大新工具的发展，小鼠遗传实验的杰出历史进一步向前推进。最近发起了几项国际倡议，通过突变、分子分析和表型分析来分析所有小鼠基因的功能，这突显了小鼠在将储存在人类基因组中的信息转化为越来越准确的人类疾病模型方面的作用。
The laboratory mouse is widely considered the model organism of choice for studying the diseases of humans, with whom they share 99% of their genes. A distinguished history of mouse genetic experimentation has been further advanced by the development of powerful new tools to manipulate the mouse genome. The recent launch of several international initiatives to analyse the function of all mouse genes through mutagenesis, molecular analysis and phenotyping underscores the utility of the mouse for translating the information stored in the human genome into increasingly accurate models of human disease.