THE INTER-RELATIONSHIPS BETWEEN OVARIAN-INDEPENDENT GROWTH, TUMORIGENICITY, INVASIVENESS AND ANTIOESTROGEN RESISTANCE IN THE MALIGNANT PROGRESSION OF HUMAN-BREAST CANCER
THE INTER-RELATIONSHIPS BETWEEN OVARIAN-INDEPENDENT GROWTH, TUMORIGENICITY, INVASIVENESS AND ANTIOESTROGEN RESISTANCE IN THE MALIGNANT PROGRESSION OF HUMAN-BREAST CANCER
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DOI：
10.1677/joe.0.1220331
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发表时间：
1989-07-01
影响因子：
4
通讯作者：
LIPPMAN, ME
中科院分区：
文献类型：
--
作者：
CLARKE, R;BRUNNER, N;LIPPMAN, ME
在乳腺癌中导致高度恶性表型的进行性获得的过程中，有卵巢非依赖性生长、抗雌激素抗性和转移潜能增加。我们以前已经观察到，增加的侵袭性和卵巢非依赖性生长的发展独立发生。为了进一步明确这些过程之间的相互关系，我们比较了卵巢依赖性人乳腺癌细胞系MCF-7的卵巢非依赖性、侵袭性和抗雌激素耐药亚系的表型。获得卵巢非依赖性生长的细胞可以保持对抗雌激素的敏感性。选择稳定抗雌激素抗性的MCF-7细胞的一个克隆已成为非致瘤性的，但其侵袭潜力保持不变。因此，进展表型的某些特征的获得可以独立地发生。这种现象的独立参数的表型进展可以部分解释相当大的内部和肿瘤间的异质性特征的乳腺肿瘤。
Among the processes contributing to the progressive acquisition of the highly malignant phenotype in breast cancer are ovarian-independent growth, antioestrogen resistance and increased metastatic potential. We have previously observed that increased invasiveness and development of ovarian-independent growth occur independently. In an attempt to define the inter-relationships between these processes further, we have compared the phenotypes of ovarian-independent, invasive and antioestrogen-resistant sublines of the ovarian-dependent human breast cancer cell line MCF-7. Cells acquiring ovarian-independent growth can retain sensitivity to anti-oestrogens. One clone of MCF-7 cells selected for stable antioestrogen resistance has become non-tumorigenic but its invasive potential remains unaltered. Thus, acquisition of some characteristics of the progressed phenotype can occur independently. This phenomenon of independent parameters in phenotypic progression could partly explain the considerable intra- and intertumour heterogeneity characteristic of breat tumours.