GM1 ganglioside improves spatial learning and memory of aged rats
GM1 ganglioside improves spatial learning and memory of aged rats
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DOI：
10.1016/s0166-4328(97)87584-5
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发表时间：
1997-05-01
影响因子：
2.7
通讯作者：
Hadjiconstantinou, M
中科院分区：
文献类型：
--
作者：
Fong, TG;Neff, NH;Hadjiconstantinou, M
GM 1神经节苷脂，30 mg/kg，腹腔注射，给予认知受损的老年大鼠30天，并在Morris水迷宫范例中评价空间学习和记忆。在用GM 1治疗期间，老年动物改善了位置导航的获得和保持，如通过减少逃避潜伏期和游泳到隐藏平台的距离所反映的，并且持续表现优于老年对照动物。此外，当移除隐藏平台时，GM 1处理的动物在空间探测测试中显示出改善的空间敏锐度。如果停止GM 1治疗，并且动物在15天后进行测试，则在定位导航中的改善性能不会丧失。GM 1处理对幼年大鼠在水迷宫中的表现没有影响。这些结果表明，与衰老相关的记忆缺陷可以通过用GM 1神经节苷脂治疗来减弱。
GM1 ganglioside, 30 mg/kg, i.p., was administered to cognitively impaired aged rats for 30 days, and spatial learning and memory evaluated in a Morris water maze paradigm. During treatment with GM1, aged animals improved both the acquisition and retention of place navigation, as reflected by reduced escape latencies and swim distances to a hidden platform, and persistently performed better than the aged control animals. Furthermore, the GM1-treated animals showed improved spatial acuity in a spatial probe test when the hidden platform was removed. The improved performance in place navigation was not lost if GM1 treatment was discontinued and the animals tested up to 15 days later. GM1 treatment had no effect on the performance of young rats in the water maze. These results indicate that memory deficits associated with aging can be attenuated by treatment with GM1 ganglioside.