XPA: A key scaffold for human nucleotide excision repair.
XPA: A key scaffold for human nucleotide excision repair.
复制标题
DOI：
10.1016/j.dnarep.2016.05.018
复制
发表时间：
2016-08
期刊：
影响因子：
3.8
通讯作者：
Chazin WJ
中科院分区：
文献类型：
--
作者：
Sugitani N;Sivley RM;Perry KE;Capra JA;Chazin WJ
核苷酸切除修复（NER）对于从基因组中去除许多类型的DNA损伤是必不可少的，但人类NER的机制仍然知之甚少。这篇综述总结了我们目前对关键NER蛋白之一XPA的结构、生物化学、相互作用伙伴、机制和疾病相关突变的理解。
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.