Autoimmune thyroid dysfunction in the postpartum period.
Autoimmune thyroid dysfunction in the postpartum period.
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产后期自身免疫性甲状腺功能障碍。
DOI：
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发表时间：
1984
影响因子：
5.8
通讯作者：
G. Nilsson
中科院分区：
文献类型：
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作者：
R. Jansson;S. Bernander;A. Karlsson;K. Levin;G. Nilsson
对 460 名白人妇女产后甲状腺疾病的患病率进行了调查。在 44 名 (9.6%) 女性中发现了甲状腺微粒体抗体 (MsAb)。这些女性似乎患有自身免疫性甲状腺炎。 MsAb 滴度的变化遵循可预测的模式，在产后 5-7 个月左右达到最大值。此时，其中 20 名女性患有短暂性甲状腺功能减退症，其中一些女性在此之前曾出现过甲状腺毒症发作。产后甲状腺功能减退的程度与妊娠早期和产后期的 MsAb 滴度密切相关。 8 名妇女在产后 5-7 个月内出现短暂性甲状腺毒症。在其中四名女性中检测到 TSH 受体刺激抗体和/或高放射性碘摄取，提示格雷夫斯病。因此，分娩后，自身免疫性甲状腺疾病的表现非常常见。在患有自身免疫性甲状腺炎的患者中，MsAb 的测量为短暂性甲状腺功能减退的发展提供了良好的预后标志。
The prevalence of thyroid disease was investigated in 460 Caucasian women after delivery. Thyroid microsomal antibodies (MsAb) were found in 44 (9.6%) of the women. These women appeared to have autoimmune thyroiditis. The changes in MsAb titers followed a predictable pattern with maximal values around 5-7 months postpartum. At this time 20 of these women had transient hypothyroidism and in some this was preceded by a thyrotoxic episode. The extent of postpartum hypothyroidism correlated well with the titers of MsAb in early pregnancy and in the postpartum period. Transient thyrotoxicosis occurred in eight women 5-7 months postpartum. TSH-receptor stimulating antibodies and/or high radioiodine uptake, suggesting Graves' disease, were detected in four of these women. Thus, after delivery, manifestations of autoimmune thyroid disorders, are remarkably common. In patients with autoimmune thyroiditis measurements of MsAb provide a good prognostic marker for the development of transient hypothyroidism.