Personal exposure to benzene, toluene, ethylbenzene, and xylenes (BTEXs) mixture and telomere length: A cross-sectional study of the general US adult population.
Personal exposure to benzene, toluene, ethylbenzene, and xylenes (BTEXs) mixture and telomere length: A cross-sectional study of the general US adult population.
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DOI：
10.1016/j.envres.2022.112810
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发表时间：
2022-01
影响因子：
8.3
通讯作者：
Z. Niu;X. Wen;Meng Wang;L. Tian;Lina Mu
中科院分区：
文献类型：
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作者：
Z. Niu;X. Wen;Meng Wang;L. Tian;Lina Mu
背景苯、甲苯、乙苯和二甲苯（BTEX）是一组来自化石燃料的芳香族大气污染物。有没有研究协会的BTEX的混合物与端粒长度（TL），细胞衰老的标志物，在一般population.MethodsWe分析了一个子样本的549名美国成年人，年龄在20 - 59岁的国家健康和营养检查调查1999 - 2000。BTEX样品由参与者佩戴48 - 72 h的被动暴露徽章收集。用气相色谱/质谱法测量BTEX的水平。用qPCR测量白细胞TL。我们使用贝叶斯核机器回归（BKMR）来检查BTEX混合物对调整潜在混杂因素的TL的影响。分析分层吸烟状态（血清可替宁≥ 10 ng/mL与<10 ng/mL）。结果BTEX的个人暴露水平在大多数参与者中是可检测的，相对较高的150吸烟者比399非吸烟者。BTEX呈中度或强相关（0.5 <r ≤ 0.9，P <0.05）。所有化学物质与TL呈弱负相关（-0.1 <r <0，P> 0.05）。在非吸烟者的BKMR模型中，BTEX混合物在BTEX的低范围（第20 - 65百分位数）与TL显著负相关，但在较高范围（> 65百分位数）与TL无关。此外，我们发现了一个U形协会的苯和积极的协会与TL的苯系物独立于其他BTEX。在吸烟者中，无论是BTEX的混合物，也没有任何个人BTEX显着与TL. ConclusionWithin低到中等范围内，暴露于BTEX的混合物可能与较短的端粒长度在一般非吸烟人群。
BackgroundBenzene, Toluene, Ethylbenzene, and Xylenes (BTEXs) are a group of aromatic air pollutants from fossil fuels. There is no research on associations of the BTEXs mixture with telomere length (TL), a marker of cellular aging, in the general population.MethodsWe analyzed a subsample of 549 US adults aged 20–59 years from the National Health and Nutrition Examination Survey 1999–2000. BTEXs samples were collected by passive exposure badges worn by participants for 48–72 h. Levels of BTEXs were measured with gas chromatography/mass spectrometry. Leukocyte TL was measured with qPCR. We used Bayesian Kernel Machine Regression (BKMR) to examine the effect of the BTEXs mixture on TL adjusting for potential confounders. Analyses were stratified by tobacco smoking status (serum cotinine≥10 ng/mL vs. <10 ng/mL).ResultsLevels of personal exposure to BTEXs were detectable in most participants and were relatively higher in the 150 smokers than in the 399 nonsmokers. The BTEXs were moderately or strongly intercorrelated (0.5 < r ≤ 0.9, P < 0.05). All chemicals had weak, inverse correlations with TL (−0.1<r < 0, P > 0.05). In BKMR models among the nonsmokers, the BTEXs mixture was significantly inversely associated with TL at a low range of the BTEXs (20th-65th percentile) but was not associated with TL at a higher range (>65th percentile). Also, we found a U-shape association of benzene and a positive association of ethylbenzene with TL independent of other BTEXs. Among smokers, neither the BTEXs mixture nor any individual BTEXs were significantly associated with TL.ConclusionWithin a low-to-middle range, exposure to the BTEXs mixture may be associated with shorter telomere length in the general nonsmoking population.