Antibody to Varicella-Zoster virus in parturient women and their offspring during the first year of life.
Antibody to Varicella-Zoster virus in parturient women and their offspring during the first year of life.
复制标题
产妇及其后代第一年的水痘带状疱疹病毒抗体。
DOI：
10.1542/peds.58.5.692
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发表时间：
1976
期刊：
影响因子：
8
通讯作者：
L. Drusin
中科院分区：
文献类型：
--
作者：
A. Gershon;R. Raker;S. Steinberg;B. Topf;L. Drusin
据报道，苗圃爆发了水痘疫情。研究人员对 200 名产妇及其 131 名后代的血清进行了水痘带状疱疹 (V-Z) 病毒抗体研究，以分析她们对水痘的免疫力。通过膜抗原敏感荧光抗体（FAMA）技术测量抗体滴度。研究发现，纽约市约 5% 至 16% 的育龄妇女易患水痘。来自波多黎各或其他亚热带和热带地区的女性 (16%) 比其他地区的女性 (5%) 更容易受到影响。具有可检测到的 V-Z FAMA 滴度的母亲所生的婴儿在出生时几乎总是具有可检测到的 V-Z 抗体。在从 67 名最初血清反应阳性的婴儿出生后第一年采集的连续血清样本中，发现到 6 个月大时，大多数婴儿不再被动地预防水痘。这些观察结果可以解释为什么水痘在小婴儿中并不罕见。
A nursery outbreak of varicella is reported. Serum from 200 parturient women and 131 of their offspring were studied for antibody to varicella-zoster (V-Z) virus to analyze their immunity to varicella. Antibody titers were measured by the sensitive fluorescent antibody to membrane antigen (FAMA) technique. It was found that approximately 5% to 16% of women of child-bearing age in New York City are susceptible to varicella. Women from Puerto Rico or other subtropical and tropical areas are more likely to be susceptible (16%) than others (5%). Infants born to mothers with detectable V-Z FAMA titers almost always had detectable V-Z antibody at birth. In serial serum specimens obtained from 67 initially seropositive babies during the first year of life, it was found that by 6 months of age most infants were no longer passively protected against varicella. These observations may explain why varicella is not uncommonly observed in young babies.