Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level.
Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level.
复制标题
慢性多巴胺受体阻断对 D2 多巴胺受体 mRNA 水平缺乏影响。
DOI：
10.1016/0304-3940(90)90279-i
复制
发表时间：
1990
影响因子：
2.5
通讯作者：
Creese,I
中科院分区：
文献类型：
--
作者：
vanTol,HH;Riva,M;Civelli,O;Creese,I
长期服用抗精神病药物增加纹状体D2多巴胺受体的大鼠并没有明显增加D2受体的mRNA水平，这表明所观察到的受体增加主要不是由于转录调节。这些和其他数据表明，受体调节对去神经或神经递质耗竭的反应可能与对拮抗剂药物慢性受体阻断的反应不同。
The chronic treatment of rats with antipsychotic drugs which increase striatal D2dopamine receptors did not measurably increase the level of D2receptor mRNA indicating that the observed increase in receptors was not primarily due to transcriptional regulation. These and other data suggest that the molecular mechanisms involved in receptor regulation in response to denervation or neurotransmitter depletion may be different from those which occur in response to chronic receptor blockade by antagonist drugs.