The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis.
The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis.
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m6A 核糖核酸修饰在动脉粥样硬化发生中的作用。
DOI：
10.3389/fgene.2021.733871
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发表时间：
2021
影响因子：
3.7
通讯作者：
Cui X
中科院分区：
文献类型：
--
作者：
Fu J;Cui X;Zhang X;Cheng M;Li X;Guo Z;Cui X
N6-甲基腺苷(M6A)修饰是真核生物信使RNA(MRNA)中含量最丰富的表位转录修饰。M6A的修饰过程受多种酶和蛋白质的共同调控，如甲基转移酶、去甲基酶和相关的M6A结合蛋白。这个过程是动态的和可逆的，在mRNA代谢和各种生物学活动中起着至关重要的作用。近年来，越来越多的研究人员证实，许多疾病的发生发展与m6A RNA甲基化的分子生物学机制密切相关。本研究旨在探讨M6A RNA修饰与动脉粥样硬化(AS)的关系。全面综述了AS相关细胞中m6A RNA修饰的机制、过程及其与AS危险因素的关系，为AS的早期诊断和治疗寻找新的靶点提供参考。
The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases and related m6A-binding proteins. The process is dynamic and reversible, and it plays an essential role in mRNA metabolism and various biological activities. Recently, an increasing number of researchers have confirmed that the onset and development of many diseases are closely associated with the molecular biological mechanism of m6A RNA methylation. This study focuses on the relationship between m6A RNA modification and atherosclerosis (AS). It thoroughly summarizes the mechanisms and processes of m6A RNA modification in AS-related cells and the relationships between m6A RNA modification and AS risk factors, and it provides a reference for exploring new targets for the early diagnosis and treatment of AS.
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
5.3
作者：
CAMPER, SA;ALBERS, RJ;ROTTMAN, FM
通讯作者：
ROTTMAN, FM
影响因子：
16.6
作者：
Cui YH;Yang S;Wei J;Shea CR;Zhong W;Wang F;Shah P;Kibriya MG;Cui X;Ahsan H;He C;He YY
通讯作者：
He YY
DOI：
10.1126/science.1151710
发表时间：
2007-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerken T;Girard CA;Tung YC;Webby CJ;Saudek V;Hewitson KS;Yeo GS;McDonough MA;Cunliffe S;McNeill LA;Galvanovskis J;Rorsman P;Robins P;Prieur X;Coll AP;Ma M;Jovanovic Z;Farooqi IS;Sedgwick B;Barroso I;Lindahl T;Ponting CP;Ashcroft FM;O'Rahilly S;Schofield CJ
通讯作者：
Schofield CJ
影响因子：
20.1
作者：
Herrington, William;Lacey, Ben;Lewington, Sarah
通讯作者：
Lewington, Sarah