Ghrelin for cachexia.
Ghrelin for cachexia.
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DOI：
10.1007/s13539-010-0011-5
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发表时间：
2010-12
影响因子：
8.9
通讯作者：
Kangawa, Kenji
中科院分区：
文献类型：
--
作者：
Akamizu, Takashi;Kangawa, Kenji
Ghrelin是生长激素（GH）促分泌素受体的天然配体，主要在胃中产生。在动物和人类中，Ghrelin的施用刺激食物摄入和GH分泌。Ghrelin是已知的唯一刺激人类食欲的循环激素。由于生长激素是一种合成代谢激素，在热量限制的条件下，蛋白质储存是以脂肪为代价的。Ghrelin还抑制厌食促炎细胞因子的产生。因此，ghrelin通过GH依赖性和非依赖性机制表现出抗恶病质作用。几项研究正在评估生长激素释放肽在治疗由各种疾病引起的恶病质中的疗效，包括充血性心力衰竭、慢性阻塞性肺病、癌症和终末期肾病。这些研究将有望导致新的临床应用的生长激素释放肽在未来的发展。这些研究也有助于更好地了解生长激素释放肽的抗分解代谢作用的分子基础。本文综述了近年来在这一领域的研究进展。
Ghrelin, a natural ligand for the growth hormone (GH)-secretagogue receptor, is primarily produced in the stomach. Administration of ghrelin stimulates food intake and GH secretion in both animals and humans. Ghrelin is the only circulating hormone known to stimulate appetite in humans. As GH is an anabolic hormone, protein stores are spared at the expense of fat during conditions of caloric restriction. Ghrelin also inhibits the production of anorectic proinflammatory cytokines. Thus, ghrelin exhibits anti-cachectic actions via both GH-dependent and -independent mechanisms. Several studies are evaluating the efficacy of ghrelin in the treatment of cachexia caused by a variety of diseases, including congestive heart failure, chronic obstructive pulmonary disease, cancer, and end-stage renal disease. These studies will hopefully lead to the development of novel clinical applications for ghrelin in the future. These studies have also facilitated a better understanding of the molecular basis of the anti-catabolic effects of ghrelin. This review summarizes the recent advances in this area of research.
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影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
5.8
作者：
Akamizu, T;Takaya, K;Kangawa, K
通讯作者：
Kangawa, K
影响因子：
4.8
作者：
DeBoer, Mark D.;Zhu, Xin Xia;Marks, Daniel L.
通讯作者：
Marks, Daniel L.
影响因子：
4.8
作者：
DeBoer, Mark D.;Zhu, Xinxia;Marks, Daniel L.
通讯作者：
Marks, Daniel L.
DOI：
10.1111/j.1532-5415.2004.52156.x
发表时间：
2004-04-01
影响因子：
6.3
作者：
Bach, MA;Rockwood, K;Fuh, V
通讯作者：
Fuh, V