Electrical interactions via the extracellular potential near cell bodies
Electrical interactions via the extracellular potential near cell bodies
复制标题
DOI：
10.1023/a:1008832702585
复制
发表时间：
1999-03-01
影响因子：
1.2
通讯作者：
Koch, C
中科院分区：
文献类型：
--
作者：
Holt, GR;Koch, C
原则上，神经元和轴突或树突之间的相互作用比纤维束中轴突之间的相互作用更重要。轴突外的细胞外动作电位幅度小，空间分散，而它们的幅度较大，空间上更局限于细胞体附近。我们估计的细胞外电位与动作电位在皮质锥体细胞使用标准的一维电缆理论和体积导体理论。它们的空间和时间模式揭示了细胞中电流的位置和时间，特别是与已知形态相结合，简单的实验可以解决有关尖峰启动的问题。从细胞外电位，我们计算在附近的无源电缆ephaptically诱导极化。该感应电压的幅度可以是几mV，不会以电张力的方式传播，并且仅微弱地取决于电缆的无源特性。我们讨论了它们可能的功能相关性。
Ephaptic interactions between a neuron and axons or dendrites passing by its cell body can be, in principle, more significant than ephaptic interactions among axons in a fiber tract. Extracellular action potentials outside axons are small in amplitude and spatially spread out, while they are larger in amplitude and much more spatially confined near cell bodies. We estimated the extracellular potentials associated with an action potential in a cortical pyramidal cell using standard one-dimensional cable theory and volume conductor theory. Their spatial and temporal pattern reveal much about the location and timing of currents in the cell, especially in combination with a known morphology, and simple experiments could resolve questions about spike initiation. From the extracellular potential we compute the ephaptically induced polarization in a nearby passive cable. The magnitude of this induced voltage can be several mV, does not spread electrotonically, and depends only weakly on the passive properties of the cable. We discuss their possible functional relevance.