Unravelling Leber hereditary optic neuropathy
Unravelling Leber hereditary optic neuropathy
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揭开莱伯遗传性视神经病的谜团
DOI：
10.1136/bjo.86.9.956
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发表时间：
2002
影响因子：
4.1
通讯作者：
P. Goh
中科院分区：
文献类型：
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作者：
M. Zainal;S. Ismail;A. Ropilah;H. Elias;G. Arumugam;D. Alias;J. Fathilah;T. Lim;L. Ding;P. Goh
背景资料：1996年进行了一次全国眼科调查，以确定马来西亚所有年龄人口中失明和低视力的流行率及其主要原因。方法：采用分层二阶段整群抽样设计，随机抽取一、二级抽样单位。对抽样家庭的所有个人进行了访谈、视力测试和眼科检查。估计值通过调整选择概率、无应答和抽样覆盖率的因素进行加权。结果：整体回应率为69%（即住宅回应率为72.8%，住户回应率为95.1%）。年龄校正的双眼盲和低视力患病率分别为0.29%（95%CI 0.19 ~ 0.39%）和2.44%（95%CI 2.18 ~ 2.69%）。与男性相比，女性的年龄调整后低视力患病率更高。4个民族、城乡居民双眼低视力和盲的患病率差异无统计学意义。白内障是致盲的主要原因（39%），其次是视网膜疾病（24%）。未矫正屈光不正（48%）和白内障（36%）是导致低视力的主要原因。结论：马来西亚的失明和视力障碍率与东南亚地区的其他国家相当。然而，白内障和未矫正的屈光不正虽然容易治疗，但仍然是失明的主要原因，这表明需要对该国眼科护理服务的可及性和可用性以及眼科护理利用的障碍进行评估。
Background: A national eye survey was conducted in 1996 to determine the prevalence of blindness and low vision and their major causes among the Malaysian population of all ages. Methods: A stratified two stage cluster sampling design was used to randomly select primary and secondary sampling units. Interviews, visual acuity tests, and eye examinations on all individuals in the sampled households were performed. Estimates were weighted by factors adjusting for selection probability, non-response, and sampling coverage. Results: The overall response rate was 69% (that is, living quarters response rate was 72.8% and household response rate was 95.1%). The age adjusted prevalence of bilateral blindness and low vision was 0.29% (95% CI 0.19 to 0.39%), and 2.44% (95% CI 2.18 to 2.69%) respectively. Females had a higher age adjusted prevalence of low vision compared to males. There was no significant difference in the prevalence of bilateral low vision and blindness among the four ethnic groups, and urban and rural residents. Cataract was the leading cause of blindness (39%) followed by retinal diseases (24%). Uncorrected refractive errors (48%) and cataract (36%) were the major causes of low vision. Conclusion: Malaysia has blindness and visual impairment rates that are comparable with other countries in the South East Asia region. However, cataract and uncorrected refractive errors, though readily treatable, are still the leading causes of blindness, suggesting the need for an evaluation on accessibility and availability of eye care services and barriers to eye care utilisation in the country.
影响因子：
--
作者：
TIELSCH, JM;SOMMER, A;ROYALL, RM
通讯作者：
ROYALL, RM