Transition of Serum Alkaline Phosphatase Isoenzymes during Liver Regeneration in Humans
Transition of Serum Alkaline Phosphatase Isoenzymes during Liver Regeneration in Humans
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DOI：
10.5754/hge11097
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发表时间：
2011-09-01
影响因子：
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通讯作者：
Eguchi, Susumu
中科院分区：
文献类型：
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作者：
Muraoka, Izumi;Soyama, Akihiko;Eguchi, Susumu
背景/目的：肝切除后血清碱性磷酸酶(ALP)水平有升高的趋势，然而，以往的研究尚未集中于肝再生与个体ALP同工酶水平的关系。方法：对40例行半肝切除的活体肝移植供者进行研究。观察手术前后血清碱性磷酸酶(ALP)和碱性磷酸酶(ALP)同工酶水平。用体积法计算肝再生率(LRR)。根据LRR将供者分为两组，高再生组(HG)和低再生组(LG)。结果：肝切除后血清总ALP水平逐渐升高，术后14d达高峰，所有供者术前均未检测到ALP-1，术后7d检测到ALP-1，术后血清ALP-2水平升高，术后14d达高峰，两组术后ALP-2水平逐渐升高，术后14d达高峰。然而，HG在POD 14时的ALP-2水平显著高于LG。结论：术后14天血清ALP-2水平可能是肝切除术后良好肝再生的有用指标，尤其是在肝功能正常的患者。然而，以往的研究尚未集中于肝再生与个体ALP同工酶水平之间的关系。方法：本研究调查了40例接受半肝切除的活体肝移植供者。观察手术前后血清碱性磷酸酶(ALP)和碱性磷酸酶(ALP)同工酶水平。用体积法计算肝再生率(LRR)。根据LRR将供者分为高再生组(HG)和低再生组(LG)。结果：肝切除后血清总ALP水平逐渐升高，术后第14天达到高峰。血清ALP-2水平在肝切除后升高，于术后14天达高峰，术后逐渐升高，于术后14天达高峰。HG组术后14d血清ALP-2水平明显高于正常对照组。结论：术后14d血清ALP-2水平可能是肝切除术后肝再生良好的指标，尤其是肝功能正常的患者。
Background/Aims: Serum alkaline phosphatase (ALP) levels tend to increase after hepatectomy, however, no previous examinations have yet focused on the relationship between liver regeneration and the individual ALP isoenzymes levels. Methodology: Forty living liver transplantation donors who underwent hemi-hepatectomy were herein investigated. We evaluated the serum ALP levels and ALP isoenzyme levels preoperatively and postoperatively. The liver regeneration rate (LRR) was calculated using volumetry. According to the LRR, we divided the donors into two groups, consisting of a high regeneration group (HG) and a low regeneration group (LG). Results: The total serum ALP levels increased gradually after hepatectomy and peaked on postoperative days (POD) 14. ALP-1 was not detected in any donor preoperatively; however it was detected after hepatectomy, peaking on POD 7. The serum ALP-2 level increased after hepatectomy, reaching a peak level on POD 14. The ALP-2 levels gradually increased after hepatectomy and reached peak levels on POD 14 in both groups. However, the ALP-2 level on POD 14 was significantly higher in HG than LG. Conclusions: The serum ALP- 2 levels after POD 14 might therefore be a useful indicator of favorable liver regeneration following hepatectomy, especially in patients who have a normal liver function.Background/Aims: Serum alkaline phosphatase (ALP) levels tend to increase after hepatectomy. However, no previous examinations have yet focused on the relationship between liver regeneration and the individual ALP isoenzymes level.Methodology: Forty living liver transplantation donors who underwent hemi-hepatectomy were herein investigated. We evaluated the serum ALP levels and ALP isoenzyme levels preoperatively and postoperatively. The liver regeneration rate (LRR) was calculated using volumetry. According to the LRR, we divided the donors into two groups, consisting of a high regeneration group (HG) and a low regeneration group (LG).Results: The total serum ALP levels increased gradually after hepatectomy and peaked on postoperative day (POD) 14. ALP-1 was not detected in any donor preoperatively. However, it was detected after hepatectomy, peaking on POD 7. The serum ALP-2 level increased after hepatectomy, reaching a peak level on POD 14. The ALP-2 levels gradually increased after hepatectomy and reached peak levels on POD 14 in both groups. However, the ALP-2 level on POD 14 was significantly higher in HG than LG.Conclusions: The serum ALP-2 levels after POD 14 might therefore be a useful indicator of favorable liver regeneration following hepatectomy, especially in patients who have a normal liver function.