Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice
Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice
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DOI：
10.1016/s0002-9440(10)61172-8
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发表时间：
2002-06-01
影响因子：
6
通讯作者：
Warner, T
中科院分区：
文献类型：
--
作者：
Balish, E;Warner, T
无菌白细胞介素-10基因敲除（IL-10 KO）小鼠在用粪肠球菌纯培养物定殖后发生炎症性肠病（IBD）。粪肠球菌不仅诱导IBD（主要在结肠和直肠），但直肠发育不良和腺癌也发现在IL-10 KO小鼠。常规（复杂肠道植物群）IL-10 KO小鼠在10至15周龄内发展IBD，并且在盲肠中显示更多病理学。（盲肠炎）比我们在粪肠球菌诱导的IBD中观察到的更好。相反，无菌IL-10小鼠和IL-10 KO小鼠在成年时都没有定植，用白色念珠菌、大肠杆菌、干酪乳杆菌、乳酸杆菌、n.罗伊特湖在25- 30周的研究中，嗜酸乳杆菌、双歧杆菌、乳酸乳球菌或芽孢杆菌发展为IBD。粪肠球菌是人类和动物的常见肠道微生物，其可在遗传易感的鼠宿主中引发IBD、发育不良和癌。
Germ-free interleukin-10 knockout (IL-10 KO) mice developed inflammatory bowel disease (IBD) after they were colonized with a pure culture of Enterococcus faecalis. E faecalis not only induced IBD (primarily in colon and rectum) but rectal dysplasia and adenocarcinoma was also found in the IL-10 KO mice. Conventional (complex-intestinal flora) IL-10 KO mice developed IBD within 10 to 15 weeks of age and showed more pathology in the cecum. (typhlitis) than we observed with E faecalis-induced IBD in gnotobiotic IL-10 KO mice. Conversely, neither germ-free IL-10 mice nor IL-10 KO mice colonized as adults, with a pure culture of Candida albicans, Escherichia coli, Lactobacillus casei, L. reuteri, L. acidophilus, a Bifidobacterium sp, Lactococcus lactis, or a Bacillus sp. developed IBD during the 25- to 30-week study. E faecalis is a common intestinal microbe of man and animals that can trigger IBD, dysplasia, and carcinoma in a genetically susceptible murine host.