NT-ProBNP levels, water and sodium homeostasis in healthy men: effects of 7 days of dry immersion
NT-ProBNP levels, water and sodium homeostasis in healthy men: effects of 7 days of dry immersion
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DOI：
10.1007/s00421-011-1858-7
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发表时间：
2011-09-01
影响因子：
3
通讯作者：
Custaud, Marc-Antoine
中科院分区：
文献类型：
--
作者：
Navasiolava, Nastassia M.;Pajot, Aurelie;Custaud, Marc-Antoine
浸没是研究流体-体积稳态的有用工具。在变化的环境条件下，利钠肽在肾脏、体液和心血管调节中起着至关重要的作用。我们假设干浸泡会迅速诱导水和钠代谢的新稳定状态，血清NT-proBNP水平（脑钠肽（BNP）的替代指标）在长期干浸泡期间会下降，在恢复期间会上升。8名健康的年轻男性在干浸泡7天之前、期间和之后进行了研究。评估体重、水分平衡和血浆容量变化。分析血浆和血清样本的活性肾素、NT-proBNP、醛固酮、电解质、渗透压、总蛋白和肌酐。分析尿液样本以确定电解质、渗透压、肌酐和游离皮质醇的水平。在干浸泡前后进行站立试验以评估心血管状况。长期干浸渍在第1天引起急性水钠稳态变化，随后进入新的稳态。干浸渍过程中血浆体积显著减少。恢复后血清NT-proBNP水平显著升高（干浸前为10 +/- 3 ng/L，恢复第4天为26 +/- 5 ng/L）。浸泡后站立位心率显著增高。结果表明，长期干浸泡可迅速诱导水电解质稳态达到一个新的水平。恢复期NT-proBNP水平的增加可能与心脏工作增加有关，并可能反映心血管疾病的程度。
Immersion is a useful tool for studying fluid-volume homeostasis. Natriuretic peptides play a vital role in renal, humoral, and cardiovascular regulation under changing environmental conditions. We hypothesized that dry immersion would rapidly induce a new steady state for water and sodium metabolism, and that serum NT-proBNP levels, a proxy measure for brain natriuretic peptide (BNP), would decrease during long-term dry immersion and increase during recovery. Eight healthy young men were studied before, during, and after 7 days of dry immersion. Body weight, water balance, and plasma volume changes were evaluated. Plasma and serum samples were analyzed for active renin, NT-proBNP, aldosterone, electrolytes, osmolality, total protein, and creatinine. Urine samples were analyzed to determine levels of electrolytes, osmolality, creatinine, and free cortisol. A stand test was performed before and after dry immersion to evaluate cardiovascular deconditioning. Long-term dry immersion induced acute changes in water and sodium homeostasis on day 1, followed by a new steady state. Plasma volume decreased significantly during dry immersion. The serum levels of NT-proBNP increased significantly in recovery (10 +/- 3 ng/L before dry immersion vs. 26 +/- 5 ng/L on the fourth recovery day). Heart rate in the standing position was significantly greater after immersion. Results suggest that chronic dry immersion rapidly induced a new level of water-electrolyte homeostasis. The increase in NT-proBNP levels during the recovery period may be related to greater cardiac work and might reflect the degree of cardiovascular deconditioning.