Global burden of gastric cancer attributable to Helicobacter pylori
Global burden of gastric cancer attributable to Helicobacter pylori
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DOI：
10.1002/ijc.28999
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发表时间：
2015-01-15
影响因子：
6.4
通讯作者：
de Martel, Catherine
中科院分区：
文献类型：
--
作者：
Plummer, Martyn;Franceschi, Silvia;de Martel, Catherine
我们此前估计，2008年有66万例癌症是由幽门螺杆菌(H.Pylori)引起的，占全球1270万癌症病例总数的5.2%。近年来，越来越多的证据表明，免疫印迹法(Western印迹)对检测抗-H更敏感。幽门螺杆菌抗体的检测方法比我们以前分析中使用的ELISA法要好。这份简短报告的目的是在简要回顾新证据后更新幽门螺杆菌的归因分数(AF)估计，并重新评估可归因于幽门螺杆菌的全球癌症负担。因此，我们回顾了相关文献，用于比较病例和对照人群中发生非贲门型胃癌(NCGC)的风险，使用ELISA法和多重抗原免疫印迹法检测Hp。前瞻性研究的结果被结合起来，新的合并估计被应用于NCGC中幽门螺杆菌的AF的计算，然后应用于全球感染相关癌症的负担。使用基于免疫印迹的数据，NCGC中幽门螺杆菌的全球AF从74.7%增加到89.0%。这意味着大约120,000例可归因于幽门螺杆菌感染的NCGC病例总数约为780,000例(占所有癌症的6.2%而不是5.2%)。这些最新的估计加强了幽门螺杆菌作为癌症主要原因的作用。有什么新消息？在2008年估计的1270万新癌症病例中，约5.2%的病例是由幽门螺杆菌引起的，其中包括75%的非贲门型胃癌病例。然而，考虑到检测抗-H的灵敏度较低，这些百分比可能被低估了。幽门螺杆菌抗体。在这里，使用基于免疫印迹的前瞻性研究的改进估计，发现可归因于幽门螺杆菌的所有癌症和NCGC的比例分别为6.2%和89%。我们的发现加强了这种细菌作为癌症主要原因的重要性。
We previously estimated that 660,000 cases of cancer in the year 2008 were attributable to the bacterium Helicobacter pylori (H. pylori), corresponding to 5.2% of the 12.7 million total cancer cases that occurred worldwide. In recent years, evidence has accumulated that immunoblot (western blot) is more sensitive for detection of anti-H. pylori antibodies than ELISA, the detection method used in our previous analysis. The purpose of this short report is to update the attributable fraction (AF) estimate for H. pylori after briefly reviewing new evidence, and to reassess the global burden of cancer attributable to H. pylori. We therefore reviewed the literature for studies comparing the risk of developing non-cardia gastric cancer (NCGC) in cases and controls, using both ELISA and multiple antigen immunoblot for detection of H. pylori. The results from prospective studies were combined, and the new pooled estimates were applied to the calculation of the AF for H. pylori in NCGC, then to the burden of infection-related cancers worldwide. Using the immunoblot-based data, the worldwide AF for H. pylori in NCGC increased from 74.7% to 89.0%. This implies approximately 120,000 additional cases of NCGC attributable to H. pylori infection for a total of around 780,000 cases (6.2% instead of 5.2% of all cancers). These updated estimates reinforce the role of H. pylori as a major cause of cancer.What's new? Some 5.2 percent of the estimated 12.7 million new cancer cases in 2008, including 75% of non-cardia gastric cancer cases (NCGC), were attributed to the bacterium Helicobacter pylori. However, those percentages may be an underestimate, given the low sensitivity of detection of anti-H. pylori antibodies. Here, using improved estimates from prospective studies based on immunoblot, the fraction of all cancers and NCGC attributable to H. pylori was found to be 6.2 and 89% percent, respectively. Our findings reinforce the significance of the bacterium as a major cause of cancer.