CHEMOENZYMATIC SYNTHESIS OF A LIPID-LINKED CORE TRISACCHARIDE OF N-LINKED GLYCOPROTEINS
CHEMOENZYMATIC SYNTHESIS OF A LIPID-LINKED CORE TRISACCHARIDE OF N-LINKED GLYCOPROTEINS
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DOI：
10.1039/p19920002087
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发表时间：
1992-08-21
期刊：
影响因子：
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通讯作者：
TURNER, NJ
中科院分区：
文献类型：
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作者：
FLITSCH, SL;PINCHES, HL;TURNER, NJ
甘露糖基转移酶受体底物（GlcNAc）2-P（i）-P（i）-dolichyl 2的两种新类似物已经制备，其中dolichyl被植烷基4和月桂基5取代;化合物4和5都是使用容易获得的几丁质作为二糖前体合成的。化合物4作为来自猪肝和酿酒酵母的甘露糖基转移酶的有效受体底物。
Two novel analogues of the mannosyl transferase acceptor substrate (GlcNAc)2-P(i)-P(i)-dolichyl 2 have been prepared in which dolichyl is replaced by phytanyl, 4, and lauryl, 5; both compounds 4 and 5 were synthesized using readily available chitin as the disaccharide precursor. Compound 4 acts as an efficient acceptor substrate for mannosyl transferases from porcine liver and Saccharomyces cerevisiae.