Electric field causes volumetric changes in the human brain
Electric field causes volumetric changes in the human brain
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DOI：
10.7554/elife.49115
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发表时间：
2019-10-23
期刊：
影响因子：
7.7
通讯作者：
Abbott, Christopher
中科院分区：
文献类型：
--
作者：
Argyelan, Miklos;Oltedal, Leif;Abbott, Christopher
最近在电休克治疗（ECT）患者中进行的纵向神经影像学研究表明，电刺激的局部效应（偏侧）与整体癫痫发作活动（全身性）同时发生。我们在151例ECT治疗的抑郁症患者中使用电场（EF）建模，以确定EF，无偏纵向体积变化和85个脑区的抗抑郁反应之间的区域关系。大部分区域体积显著增加，体积变化与区域电场相关（t = 3.77，df = 83，r = 0.38，p=0.0003）。在控制了干扰变量（年龄、治疗次数和研究地点）后，我们确定了两个区域（左杏仁核和左海马）与EF和体积变化之间有很强的关系（FDR校正后P <0.05）。
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p