Reanalysis of the involvement of gamma-glutamyl transpeptidase in the cell activation process.
Reanalysis of the involvement of gamma-glutamyl transpeptidase in the cell activation process.
复制标题
重新分析γ-谷氨酰转肽酶在细胞活化过程中的参与。
DOI：
10.1016/s0014-5793(01)03057-5
复制
发表时间：
2001
期刊：
影响因子：
3.5
通讯作者：
Bauvois,B
中科院分区：
文献类型：
--
作者：
Antczak,C;Karp,DR;London,RE;Bauvois,B
The inhibitor of γ‐glutamyl transpeptidase (γ‐GT) acivicin modulates cellular responses including growth, myeloid maturation and apoptosis. Whether these effects result from the inhibition of γ‐GT enzyme activity remains unclear. We compared the cellular effects of acivicin against a more potent and specific inhibitor of γ‐GT (L‐2‐amino‐4‐boronobutanoic acid (L‐ABBA)) in γ‐GT‐negative (B lymphoblastoid Ramos) and γ‐GT‐positive (myelomonocytic HL‐60, γ‐GT‐transfected Ramos) cell lines. Under non‐oxidative stress conditions, acivicin‐induced cell growth arrest, apoptosis and macrophage maturation occurred independent of γ‐GT whileL‐ABBA did not influence any of these processes. Acivicin triggered tyrosine phosphorylation and increased nuclear factor κB activity. Further insight into the role of γ‐GT in cellular processes is needed.
