Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)
Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)
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DOI：
10.1016/j.envres.2010.07.003
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发表时间：
2010-10-01
影响因子：
8.3
通讯作者：
Dewailly, Eric
中科院分区：
文献类型：
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作者：
Chateau-Degat, Marie-Ludivine;Pereg, Daria;Dewailly, Eric
背景：全氟辛烷磺酸（PFOS）被用作各种商业产品的表面活性剂。在啮齿类动物中，暴露于该化合物会引起各种健康影响，包括低脂血症。全氟辛烷磺酸在人类中的潜在毒性尚未得到充分表征，但有报告指出其对脂质的影响。最近的一项研究报告称，通过饮用水接触全氟化合物的人血浆胆固醇增加，但并未报告所有接触人群中出现类似影响。全氟辛烷磺酸广泛分布于环境中，包括北极生物群。努纳维克的因纽特人因食用鱼类和野味而受到环境污染。这种饮食也是欧米伽3-多不饱和脂肪酸的来源目的：这项横断面流行病学研究旨在评估全氟辛烷磺酸暴露与血脂之间的关系，同时考虑到n-3多不饱和脂肪酸的降血脂作用。在一项大规模环境健康研究的框架内，评估了努纳维克因纽特成年人（n=723）血浆中的全氟辛烷磺酸和脂质浓度。结果：在因纽特人中，PFOS暴露和n-3 PUFAs摄入与传统食物消费有关。三酰甘油和总胆固醇与高密度脂蛋白胆固醇（HDL-C）水平的比率与全氟辛烷磺酸血浆水平呈负相关，而HDL-C水平则呈正相关，调整n-3多不饱和脂肪酸的循环水平和性别与全氟辛烷磺酸血浆水平之间的相互作用后。其他血浆脂质，如低密度脂蛋白胆固醇和非HDL-C是不相关的PFOS血浆concentration.Conclusion：本研究的结果表明，PFOS和血浆脂质水平之间的关系，在环境暴露的人群，这种影响似乎不同的n-3 PUFAs。(C)2010年爱思唯尔公司All rights reserved.
Background: Perfluorooctanesulfonate (PFOS) was used as a surfactant in various commercial products. In rodents, exposure to this compound induced various health effects, including hypolipidemia. In human populations, the potential toxicity of PFOS is not yet fully characterized, but indications of effects on lipids are reported. A recent study reported an increase in plasma cholesterol associated with exposure to perfluorinated compounds in humans exposed through drinking water, but similar effects were not reported in all exposed human populations. PFOS is widely distributed in the environment, including the arctic biota. The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega 3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols.Objective: This cross-sectional epidemiologic study aims at assessing the relationship between PFOS exposure and plasma lipids, while taking account of the concomitant hypolipidemic effect exerted by n-3 PUFAs.Methods: Plasma concentrations of PFOS and lipids were assessed in Nunavik Inuit adults (n=723) in the framework of a large-scale environmental health study. Associations of exposure levels to age, gender and selected wild food consumption associated with n-3 PUFAs intake, as well as the exposure on lipid levels were investigated by multivariate linear modeling.Results: In the Inuit population, PFOS exposure and n-3 PUFAs intake are related to traditional food consumption. Triacylglycerol and ratio of total cholesterol to high density lipoprotein cholesterol (HDL-C) levels were negatively associated with PFOS plasma levels, while HDL-C levels were positively associated, after adjustment for circulating levels of n-3 PUFAs and for the interaction between gender and PFOS plasma levels. Other plasma lipids, such as low density lipoprotein-cholesterol and non-HDL-C were not related to PFOS plasma concentrations.Conclusion: The results of this study show a relationship between PFOS and plasma lipid levels in an environmentally exposed human population, and this effect appears distinct from that of n-3 PUFAs. (C) 2010 Elsevier Inc. All rights reserved.