Endogenous platelet lectin and thrombospondin function.
Endogenous platelet lectin and thrombospondin function.
复制标题
内源性血小板凝集素和血小板反应蛋白的功能。
DOI：
10.1055/s-2007-1003503
复制
发表时间：
1987
影响因子：
5.7
通讯作者：
Gartner,TK
中科院分区：
文献类型：
--
作者：
Gartner,TK
Our interest in the structural and functional relationships of thrombospondin (TSP) as they relate to platelet aggregation is a consequence of the discovery of the endogenous platelet lectin. 1, 2 The discovery of the endogenous platelet lectin resulted directly from our attempt to determine if a platelet component or components with lectin3 or lectinlike characteristics mediates the aggregation of human platelets. We discovered that platelets stimulated with A23187, gamma-thrombin, or thrombocytin express a hemagglutination activity not expressed by resting platelets. 1, 2, 4 This hemagglutination activity is mediated by a membrane-bound, lectinlike agglutinin called the endogenous platelet lectin. 5 This agglutinin is located in the alpha-granules of resting platelets, but becomes expressed on external membranes of platelets as a consequence of secretion. 1'5 Thus, expression of the agglutinin is controlled by secretion of the contents of the alpha-granules. 2, 4-6 The observation that the same compounds that inhibit the function of the agglutinin also inhibit aggregation of platelets originally justified the view that the lectin mediates, at least in part, the aggregation of platelets. 2 Since these early aspects of the characterization of the endogenous platelet lectin have been reviewed recently, 7 details of this work will not be presented here. This article will describe the relationship between advances concerning the function and identity of the endogenous platelet lectin and the corresponding changes in our understanding of the function of TSP. This discussion will not include a detailed consideration of the contributions made by the fruitful collaboration between the groups of Frazier and Santoro, since that work is reviewed elsewhere in this issue of Seminars by Santoro.
