Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation
Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation
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DOI：
10.1191/096032799678845124
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发表时间：
1999-09-01
影响因子：
2.8
通讯作者：
Faqi, AS
中科院分区：
文献类型：
--
作者：
Dalsenter, PR;Dallegrave, E;Faqi, AS
研究了硫丹对大鼠雄性后代的生殖影响。从妊娠第15天至产后哺乳期第21天，母鼠分别口服0、1.5或3.0 mg硫丹/kg。雄性子代大鼠分别在PND 65和140（分别对应于青春期和成年期）进行研究3.0 mg硫丹/kg剂量可导致妊娠期母鼠体重下降，但对产仔数和平均出生体重没有影响。同样，睾丸下降年龄和包皮分离对雄性后代也没有影响在青春期和成年期调查时，最高剂量组的每日精子产量（x10(6)）永久性下降。然而，在最低剂量下，每日精子产量仅在青春期显著减少组织学上，显示完全精子发生的精管百分比在青春期显著减少。这一发现可能解释了在暴露于内硫胺的雄性大鼠中观察到的每日精子产量下降本研究结果表明，低剂量硫丹对发育标志或生殖和辅助性器官的重量没有明显影响。在孕期和哺乳期暴露于硫丹的雄性后代中，每日精子产量是最易受影响的终点。为了进一步了解硫丹对雄性大鼠后代的生殖影响，应该进行额外的生殖和毒性动力学研究，以确定子宫内和哺乳期雄性大鼠后代的硫丹暴露程度。
1 The reproductive effects of endosulfan on the male offspring of rats were examined. Dams were treated orally with 0, 1.5 or 3.0 mg endosulfan/kg from day 15 of pregnancy to postnatal day (PND) 21 of lactation. The male offspring rats were investigated at PND 65 or 140, corresponding to the pubertal and adulthood stage of development.2 The dose of 3.0 mg endosulfan/kg induced a decrease in maternal body weight during pregnancy, but litter size and mean birth weight were not affected. Similarly, the age at testis descent and preputial separation was not affected on the male offspring.3 The daily sperm production (x10(6)) was permanently decreased in the highest dose group when investigated at puberty and at adulthood. At the lowest dose, however, the daily sperm production was significantly reduced only at puberty.4 Histologically, the percentage of seminiferous tubules showing complete spermatogenesis was significantly decreased at puberty. This finding may explain the decrease in daily sperm production observed in the endosulfan-exposed male rats.5 The results of this study show that low doses of endosulfan have no apparent effect on developmental landmarks or on the weight of reproductive and accessory sex organ. Daily sperm production was the most susceptible endpoint in the male offspring exposed to endosulfan during pregnancy and lactation. To further understand the reproductive effects of endosulfan on male rat offspring, additional reproductive and toxicokinetic studies should be carried out to determine the extent of endosulfan exposure in male rat offspring in utero and during lactation.