Role of Angiotensin-(1-7) in Rostral Ventrolateral Medulla in Blood Pressure Regulation via Sympathetic Nerve Activity in Wistar-Kyoto and Spontaneous Hypertensive Rats
Role of Angiotensin-(1-7) in Rostral Ventrolateral Medulla in Blood Pressure Regulation via Sympathetic Nerve Activity in Wistar-Kyoto and Spontaneous Hypertensive Rats
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DOI：
10.3109/10641963.2011.583967
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发表时间：
2011-01-01
影响因子：
12.3
通讯作者：
Sunagawa, Kenji
中科院分区：
文献类型：
--
作者：
Nakagaki, Toshiaki;Hirooka, Yoshitaka;Sunagawa, Kenji
血管紧张素 (Ang)-(1-7) Ang-(1-7) 由血管紧张素 II 通过血管紧张素转换酶 2 (ACE2) 形成，并调节肾素-血管紧张素系统。我们评估了延髓头侧腹外侧 (RVLM) 中的 Ang-(1-7)-Mas 轴是否有助于血压 (BP) 调节的神经机制。我们将 Ang-(1-7)、Ang-(1-7)-Mas 受体拮抗剂 A-779 和 ACE2 抑制剂 DX600 显微注射到麻醉的 Wistar-Kyoto 大鼠 (WKY) 和自发性高血压大鼠 (SHR) 的 RVLM 中。与 WKY 相比，单侧 Ang-(1-7) 显微注射在 SHR 中引起 AP（动脉血压）显着增加。与 WKY 相比，双侧 A-779 显微注射在 SHR 中引起 AP 和肾交感神经活动显着更大的降低。双侧 DX600 显微注射引起 SHR 中 AP 的下降显着大于 WKY。我们的结果表明，RVLM 中的内源性 Ang-(1-7) 有助于维持 SHR 和 WKY 中的 AP 和肾交感神经活性，并且其活性可能在 SHR 中增强。
Angiotensin (Ang)-(1-7) Ang-(1-7) is formed from angiotensin II by angiotensin-converting enzyme 2 (ACE2) and modulates the renin-angiotensin system. We evaluated whether the Ang-(1-7)-Mas axis in the rostral ventrolateral medulla (RVLM) contributes to neural mechanisms of blood pressure (BP) regulation. We microinjected Ang-(1-7), Ang-(1-7)-Mas receptor antagonist A-779, and ACE2 inhibitor DX600 into the RVLM of anesthetized Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHRs). Unilateral Ang-(1-7) microinjection induced a significantly greater increase in AP (arterial blood pressure) in SHR than in WKY. Bilateral A-779 microinjection induced a significantly greater decrease in AP and renal sympathetic nerve activity in SHR than in WKY. Bilateral DX600 microinjection induced a significantly greater decrease in AP in SHR than in WKY. Our results suggest that endogenous Ang-(1-7) in the RVLM contributes to maintain AP and renal sympathetic nerve activity both in SHR and WKY and that its activity might be enhanced in SHR.