Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
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DOI：
10.1016/j.biopsych.2005.10.016
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发表时间：
2006-06-15
影响因子：
10.6
通讯作者：
Meaney, Michael J.
中科院分区：
文献类型：
--
作者：
Champagne, Frances A.;Meaney, Michael J.
背景：流行病学研究表明，环境逆境可以改变父母的照顾，从而影响儿童的发展。通过建立母体行为个体差异稳定的啮齿动物模型，我们探讨了应激源是否可以直接影响父母的行为。方法：哺乳期大鼠的母亲在幼崽指导的舔/梳理(LG)行为中表现出高或低的特征，并在怀孕期间受到7天的间歇性应激或对照条件的影响。雌性大鼠第三次交配，没有任何后续的干预。结果：应激使高LG组母亲的催产素受体水平和仔鼠Lg降低到与低LG组母亲相当的水平。妊娠应激/高LG母亲的成年后代在焦虑和母亲行为的行为指标以及OTR水平上与低LG母亲相似。第三次交配的结果显示，妊娠应激对母体和子代的LG都有持久的影响。这些发现表明，压力可以通过正常情况下调节这种行为的神经内分泌系统直接改变产妇的护理。因此，环境逆境的影响可以通过一种涉及产妇护理的非基因组机制在世代之间传递。
Background: Epidemiological studies suggest that environmental adversity can alter parental care and thus influence child development. We addressed the question of whether stressors can directly affect parental behavior using a rodent model of stable, individual differences in maternal behavior.Methods: Lactating rat mothers were characterized as high or low in pup-directed licking/grooming (LG) behavior, rebred, and subjected to 7 days of intermittent stress or control conditions during gestation. Female rats were mated a third time without any subsequent intervention. Maternal behavior, oxytocin receptor (OTR) binding, and offspring behavior were examined.Results: Stress reduced OTR levels and pup LG of high LG mothers to levels comparable with those of low LG mothers. The adult offspring of the gestational stress/high LG mothers resembled those of low LG mothers on behavioral measures of anxiety and maternal behavior, as well as OTR levels. The results of the third mating revealed an enduring effect of gestational stress on both mother and offspring maternal LG.Conclusions. These findings suggest that stress can directly alter maternal care through the neuroendocrine systems that normally regulate this behavior. Thus, the effects of environmental adversity can be transmitted across generations through a nongenomic mechanism involving maternal care.