Computer support for protocol-based treatment of cancer
Computer support for protocol-based treatment of cancer
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DOI：
10.1016/0743-1066(95)00094-1
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Sergot, M
中科院分区：
文献类型：
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作者：
Hammond, P;Sergot, M
癌症治疗通常在基于方案的临床试验中进行。肿瘤诊所可能会参加许多试验，每项试验都需要收集数据以监测治疗的功效和毒性。随后，对这些数据进行统计分析，以评估试验的临床目标。为了具有科学有效性，此类分析必须基于完整且正确的数据。这是引入计算机支持试验管理的推动因素之一。进一步的动机是担心治疗符合方案和患者的福祉。许多方案的复杂性、癌症危及生命的性质以及治疗副作用的毒性强调了肿瘤学的安全关键性质。 OaSiS 系统为癌症患者的基于方案的治疗提供决策支持，重点关注其所提供建议的安全性。它提供图形和电子表格样式的界面，采用逻辑数据库的完整性约束检查技术来监控协议的合规性，并在 PROLOG 中实现。本文描述了 OaSiS 的主要特征，并指出了正在进行的工作和计划的研究。
Cancer treatment is often carried out within protocol-based clinical trials. An oncology clinic may take part in many trials each of which requires data to be collected for monitoring efficacy and toxicity of treatment. Subsequently, these data are analyzed statistically to evaluate clinical objectives of the trial. To be scientifically valid, such analysis must be based on data that are both complete and correct. This is one motivating factor for introducing computer support for trial management. Further motivation is provided by concern that treatment is consistent with the protocol and the well-being of the patient. The complexity of many protocols, the life-threatening nature of cancer, and the toxicity of treatment side effects emphasize the safety-critical nature of oncology. The OaSiS system provides decision support for the protocol-based treatment of cancer patients with emphasis on the safety aspects of the advice it gives. It offers a graphical and spreadsheet-style interface, employs integrity constraint checking techniques from logic databases to monitor compliance with a protocol and is implemented in PROLOG. This paper describes the main features of OaSiS and indicates work in progress and planned research.