Autophagy in light-induced retinal damage.
Autophagy in light-induced retinal damage.
复制标题
自噬在光引起的视网膜损伤中。
DOI：
10.1016/j.exer.2015.08.021
复制
发表时间：
2016-03
影响因子：
3.4
通讯作者：
Maeda A
中科院分区：
文献类型：
--
作者：
Chen Y;Perusek L;Maeda A
视觉依赖于将光子信号转换为电子信息，由大脑解释，从而使我们能够接收到有关周围环境的信息。然而，当暴露在过度的光下时，视网膜中的光感受器和其他类型的细胞可以经历光诱导的细胞死亡，称为光诱导视网膜损伤。在这篇综述中，我们总结了目前关于过度光暴露后视网膜分子事件和光致视网膜损伤机制的知识。我们还介绍了研究自噬的潜在作用的工作，自噬是在应激条件下维持体内平衡所需的基本细胞机制，在照明视网膜和光诱导视网膜损伤的动物模型中。
Vision is reliant upon converting photon signals to electrical information which is interpreted by the brain and therefore allowing us to receive information about our surroundings. However, when exposed to excessive light, photoreceptors and other types of cells in the retina can undergo light-induced cell death, termed light-induced retinal damage. In this review, we summarize our current knowledge regarding molecular events in the retina after excessive light exposure and mechanisms of light-induced retinal damage. We also introduce works which investigate potential roles of autophagy, an essential cellular mechanism required for maintaining homeostasis under stress conditions, in the illuminated retina and animal models of light-induced retinal damage.