Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma.
Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma.
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DOI：
10.1245/s10434-015-4392-8
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发表时间：
2015-10
影响因子：
3.7
通讯作者：
Natsugoe S
中科院分区：
文献类型：
--
作者：
Matsushita D;Uenosono Y;Arigami T;Yanagita S;Nishizono Y;Hagihara T;Hirata M;Haraguchi N;Arima H;Kijima Y;Kurahara H;Maemura K;Okumura H;Ishigami S;Natsugoe S
食管鳞状细胞癌是一种侵袭性胃肠道肿瘤。迄今为止，循环肿瘤细胞（CTC）的存在已被报道为胃肠癌患者外周血中的预后因素。CellSearch系统用于分离和计数CTC。共纳入90例接受化疗或放化疗的食管鳞状细胞癌患者。治疗前后采集外周血标本。基线分析时，25例患者（27.8%）检测到CTCs。有CTC的患者的总生存期明显短于无CTC的患者。从71名患者中获得了随访血液标本。治疗后分别有32例、12例和27例患者出现部分缓解、疾病稳定和疾病进展。疾病进展组治疗后CTC阳性率（40.7%）明显高于部分缓解组（6.3%）。CTC状态从阳性变为阴性的患者与基线CTC无变化的患者一样预后良好。CTCs的检测可作为预测食管鳞癌患者肿瘤预后及放化疗疗效的一个有前景的指标。本文的在线版本（doi：10.1245/s10434-015-4392-8）包含补充材料，可供授权用户使用。
Esophageal squamous cell carcinoma is an aggressive gastrointestinal tract cancer. To date, the presence of circulating tumor cells (CTC) has been reported as a prognostic factor in peripheral blood from patients with gastrointestinal cancers. The CellSearch system was used to isolate and enumerate CTCs. A total of 90 patients with esophageal squamous cell carcinoma who received chemotherapy or chemoradiotherapy were enrolled. Peripheral blood specimens were collected before and after treatments. At baseline analysis, CTCs were detected in 25 patients (27.8 %). Overall survival was significantly shorter in patients with than without CTCs. Follow-up blood specimens were obtained from 71 patients. Partial response, stable disease, and progressive disease after treatment were seen in 32, 12, and 27 patients, respectively. CTC positivity after treatment in the progressive disease group (40.7 %) was significantly higher than that of the partial response group (6.3 %). Patients with a change in CTC status from positive to negative had a good prognosis as well as patients without baseline CTCs. Evaluation of CTCs may be a promising indicator for predicting tumor prognosis and the clinical efficacy of chemotherapy or chemoradiation therapy in patients with esophageal squamous cell carcinoma. The online version of this article (doi:10.1245/s10434-015-4392-8) contains supplementary material, which is available to authorized users.