Relationship between renal function and periodontal disease in community-dwelling elderly women with different genotypes
Relationship between renal function and periodontal disease in community-dwelling elderly women with different genotypes
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不同基因型社区老年女性肾功能与牙周病的关系
DOI：
10.1111/jcpe.12708
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发表时间：
2017
影响因子：
6.7
通讯作者：
Nakamura K.
中科院分区：
文献类型：
--
作者：
Yoshihara A;Sugita N;Iwasaki M;Wang Y;Miyazaki H;Yoshie H;Nakamura K.
ObjectivesThe的目的，本研究的目的是研究牙周病和肾功能之间的关联，在老年妇女与不同genotype.Material和MethodsA共332绝经后从不吸烟的妇女进行了分析。肾功能差定义为血清胱抑素C > 0.91 mg/l。牙周炎疾病的标志物，如牙周炎表面积（比萨）进行了评价。选定的变量，包括基于β 3肾上腺素能受体的Arg等位基因携带者和非携带者之间的比萨四分位数、体重指数（BMI）、HbA 1C和年龄，或基于过氧化物酶体增殖物激活受体γ的Ala等位基因携带者和非携带者之间的年龄，结果血清胱抑素C水平与比萨阳性率的比值比（OR）为Arg（2.52;p=0.035）和Ala等位基因非携带者（2.36;p=0.021）均为显著阳性。Arg（1.18;p=0.001）和Ala等位基因非携带者（1.12;p=0.003）的血清胱抑素C水平与BMI之间也存在显著相关性。此外，在Arg和Ala等位基因非携带者中，BMI与肾功能比萨之间的关联变得更强。
ObjectivesThe aim of this study was to examine the association between periodontal disease and renal function in elderly women with different genotypes.Material and MethodsA total of 332 postmenopausal never‐smoking women were analysed. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers such as periodontal inflamed surface area (PISA) were evaluated. Selected variables, including PISA quartile, body mass index (BMI), HbA1C and age in Arg allele carriers and non‐carriers based on the beta‐3 adrenergic receptor, or between Ala allele carriers and non‐carriers based on peroxisome proliferator‐activated receptor gamma, were analysed using multiple logistic regression analysis.ResultsThe odds ratios of serum cystatin C level and PISA (fourth quartile) were significantly positive for both Arg (2.52;p=0.035) and Ala allele non‐carriers (2.36;p=0.021). A significant association was also found between serum cystatin C level and BMI for both Arg (1.18;p=0.001) and Ala allele non‐carriers (1.12;p=0.003).ConclusionThe results of this study suggest that periodontal inflammation might be associated with renal function. Furthermore, in both the Arg and Ala allele non‐carriers, the associations between BMI and PISA for renal function became stronger.