Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes.
Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes.
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DOI：
10.4061/2011/978761
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发表时间：
2011
影响因子：
4.7
通讯作者：
Tomimoto H
中科院分区：
文献类型：
--
作者：
Ihara M;Tomimoto H
随着21世纪发达国家人口年龄结构的变化，痴呆症将成为全球最重要的健康问题之一。血管性认知障碍是仅次于阿尔茨海默病的第二种最常见的痴呆类型，并且经常导致老年人的认知能力下降。其特征在于脑血管白色物质变化;因此，为了研究涉及白色物质变化的潜在机制，开发了慢性脑灌注不足的小鼠模型，其涉及使用新设计的微弹簧圈使双侧颈总动脉变窄。本文的目的是提供一个全面的总结所取得的成就与模型，表现出良好的再现性的白色物质的变化，其特征是血脑屏障破坏，胶质细胞活化，氧化应激，少突胶质细胞的损失后，慢性脑灌注不足。该模型的详细表征可能有助于破译与记忆受损相关的底物，并朝着血管性认知障碍的更综合治疗方向发展。
With the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide. Vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease and is frequently responsible for the cognitive decline of the elderly. It is characterized by cerebrovascular white matter changes; thus, in order to investigate the underlying mechanisms involved in white matter changes, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. The purpose of this paper is to provide a comprehensive summary of the achievements made with the model that shows good reproducibility of the white matter changes characterized by blood-brain barrier disruption, glial activation, oxidative stress, and oligodendrocyte loss following chronic cerebral hypoperfusion. Detailed characterization of this model may help to decipher the substrates associated with impaired memory and move toward a more integrated therapy of vascular cognitive impairment.