Impact of rigid gas-permeable contact lens extended wear on corneal epithelial barrier function.
Impact of rigid gas-permeable contact lens extended wear on corneal epithelial barrier function.
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DOI：
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发表时间：
2002-04
影响因子：
4.4
通讯作者：
M. Lin;A. Graham;R. Fusaro;K. Polse
中科院分区：
文献类型：
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作者：
M. Lin;A. Graham;R. Fusaro;K. Polse
目的观察缺氧和闭眼对硬性透镜长期配戴（EW）时角膜上皮细胞荧光素通透性（P（dc））的影响。方法分别用光学角膜厚度计和自动扫描荧光光度计测量42例正常人的中央角膜厚度（CT）和P（dc）。所有受试者均在6晚EW方案中成功配戴硬性透气性（RGP）镜片，每个受试者随机配戴中等或高透氧性（Dk）RGP镜片（两种类型的双氢呋喃-氟碳聚合物镜片，Dk为49和92）。在下午访视（基线）时进行CT和P（dc）测量，并在过夜配戴8小时后的早晨重复测量。受试者在右眼上戴着眼罩睡觉。直至早晨测量前即刻才揭除贴片。结果中Dk组受试者的平均过夜肿胀反应大于高Dk组。配对t检验的结果表明，佩戴带有贴片的中等Dk透镜过夜的眼睛上皮渗透性显著增加。混合效应模型的结果表明，闭眼和晶状体引起的缺氧是改变P（dc）的重要因素。结论：结果表明角膜上皮通透性随低氧剂量增加而增加，整夜硬性透镜配戴损害了上皮屏障功能。
PURPOSE To measure the effect of hypoxia and eye closure on epithelial permeability to fluorescein (P(dc)) during rigid lens extended wear (EW). METHODS Central corneal thickness (CT) and P(dc) were measured in 42 subjects with an optical pachometer and automated scanning fluorophotometer, respectively. All subjects had been successfully wearing rigid gas-permeable (RGP) lenses on a 6-night EW regimen, and each individual was randomized to wear either medium- or high-oxygen-permeable (Dk) RGP lenses (two types of siloxane-fluorocarbon polymer lenses with Dk of 49 and 92). CT and P(dc) measurements were performed at an afternoon visit (baseline) and were repeated in the morning after 8 hours of overnight wear. Subjects slept with a patch over the right eye. The patch was not removed until immediately before the morning measurement. RESULTS The mean overnight swelling response for subjects in the medium-Dk group was greater than that in the high-Dk group. Results of a paired t-test indicate that the eye wearing the medium-Dk lens with a patch overnight had a significant increase in epithelial permeability. Results of mixed-effect models suggest that eye closure and lens-induced hypoxia are significant factors in altering P(dc). CONCLUSIONS The results indicate that corneal epithelial permeability increases with hypoxic dose and that epithelial barrier function is impaired by overnight rigid lens wear.