Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person
Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person
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DOI：
10.1016/j.bbi.2007.09.008
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发表时间：
2008-03-01
影响因子：
15.1
通讯作者：
Ohira, Hideki
中科院分区：
文献类型：
--
作者：
Matsunaga, Masahiro;Isowa, Tokiko;Ohira, Hideki
最近的心理神经免疫学研究表明，积极的心理事件与免疫功能有关；然而，当引发积极情绪时，有关中枢神经、内分泌和免疫系统之间关系的信息有限。在本研究中，我们通过同时记录参与者在观看以自己喜欢的人为主角的电影时唤起积极情绪时的大脑、内分泌和免疫活动，证明了这些系统之间的关联。有趣的是，当参与者经历积极情绪时，外周循环自然杀伤细胞的活性和外周多巴胺水平升高，并且这些值呈正相关。相对于对照条件，在阳性条件下以下大脑区域显着激活：内侧前额叶皮层、丘脑、下丘脑、胼胝体下回、后扣带皮层、颞上回和小脑。此外，协变量分析表明这些大脑区域与内分泌和免疫活动暂时相关。这些结果表明，当一个人经历积极情绪时，中枢神经、内分泌和免疫系统可能是相互关联的，对最喜欢的人的吸引力可能与通过多巴胺能系统激活先天免疫功能有关。 (c) 2007 Elsevier Inc. 保留所有权利。
Recent studies on psychoneuroimmunology have indicated that positive psychological events are related to immune functions; however, limited information is available regarding associations among the central nervous, endocrine, and immune systems when positive emotions are elicited. In the present study, we demonstrated associations among these systems by simultaneously recording brain, endocrine, and immune activities when positive emotions were evoked in participants as they watched films featuring their favorite persons. Interestingly, the activity of peripheral circulating natural killer cells and the peripheral dopamine level were elevated while participants experienced positive emotions, and these values were positively correlated. The following brain regions were significantly activated in the positive condition relative to the control condition: medial prefrontal cortex, thalamus, hypothalamus, subcallosal gyrus, posterior cingulate cortex, superior temporal gyrus, and cerebellum. Further, covariate analyses indicated that these brain regions were temporally associated with endocrine and immune activities. These results suggest that while an individual experiences positive emotions, the central nervous, endocrine, and immune systems may be interrelated and attraction for favorite persons may be associated with the activation of the innate immune function via the dopaminergic system. (c) 2007 Elsevier Inc. All rights reserved.