Current Issues in Mutagenesis and Carcinogenesis No. 98 - Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer
Current Issues in Mutagenesis and Carcinogenesis No. 98 - Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer
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DOI：
10.1016/s0027-5107(00)00100-7
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发表时间：
2000-11-06
影响因子：
2.3
通讯作者：
Baverstock, K
中科院分区：
文献类型：
--
作者：
Baverstock, K
辐射生物学是环境辐射风险评估的基础，但现有的辐射生物学范式无法解释辐射诱导的基因组不稳定性和旁观者效应现象。然而，这两种效应都可以用本文定性描述的动态基因组概念来理解。动态基因组的概念可能会在更好地理解生物学的其他方面，特别是一般的癌症过程和遗传修饰的后果中找到进一步的应用。(C)2000 Elsevier Science B.V.保留所有权利。
The existing paradigm governing radiobiology which is fundamental to the estimation of environmental radiation risk, cannot explain the phenomena of radiation induced genomic instability and the bystander effect. Both effects can, however, be understood in terms of the dynamical genome concept, qualitatively described herein. The dynamical genome concept may find further application in better understanding other aspects of biology, most notably the cancer process in general and the consequences of genetic modification. (C) 2000 Elsevier Science B.V. All rights reserved.