Unprecedented chain-length-dependent conformational conversion between 11/9 and 18/16 helix in α/β-hybrid peptides.
Unprecedented chain-length-dependent conformational conversion between 11/9 and 18/16 helix in α/β-hybrid peptides.
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α/β 混合肽中 11/9 和 18/16 螺旋之间前所未有的链长度依赖性构象转换。
DOI：
10.1002/anie.201407329
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发表时间：
2014
影响因子：
--
通讯作者：
M. Amblard
中科院分区：
文献类型：
--
作者：
B. Legrand;C. André;Laure Moulat;E. Wenger;C. Didierjean;E. Aubert;Marie;Jean Martínez;M. Calmès;M. Amblard
利用X射线晶体和NMR溶液结构研究了不同长度的α，β-Hybrid寡聚体，其具有交替的蛋白原性α-氨基酸和刚性β（2，3，3）-三取代双环氨基酸ABOC残基。虽然只有一个11/9的螺旋得到在固态的低聚物的长度无关，在溶液中观察到的构象多态性作为一个链长度依赖的现象。 与DFT计算一致，我们确定短的低聚物采用11/9螺旋，而18/16螺旋有利于溶液中较长的低聚物。 中间长度的低聚物发生11/9螺旋和18/16螺旋之间的快速相互转化。
α,β-Hybrid oligomers of varying lengths with alternating proteogenic α-amino acid and the rigid β(2,3,3) -trisubstituted bicyclic amino acid ABOC residues were studied using both X-ray crystal and NMR solution structures. While only an 11/9 helix was obtained in the solid state regardless of the length of the oligomers, conformational polymorphism as a chain-length-dependent phenomenon was observed in solution. Consistent with DFT calculations, we established that short oligomers adopted an 11/9 helix, whereas an 18/16 helix was favored for longer oligomers in solution. A rapid interconversion between the 11/9 helix and the 18/16 helix occurred for oligomers of intermediate length.
影响因子：
18.3
作者：
Horne, W. Seth;Gellman, Samuel H.
通讯作者：
Gellman, Samuel H.