A boundary element model of the transport of a semi-infinite bubble through a microvessel bifurcation
A boundary element model of the transport of a semi-infinite bubble through a microvessel bifurcation
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DOI：
10.1063/1.3442829
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发表时间：
2010-06-01
影响因子：
4.6
通讯作者：
Bull, Joseph L.
中科院分区：
文献类型：
--
作者：
Calderon, Andres J.;Eshpuniyani, Brijesh;Bull, Joseph L.
出于发展气体栓塞治疗技术选择性闭塞血流到肿瘤，我们研究了运输的压力驱动的半无限气泡通过充满液体的分叉通道。当气泡通过血管分叉时气泡分裂的均匀性影响肿瘤附近的血管网络可以被均匀闭塞的程度。汽泡分裂的均匀性随汽泡驱动压力的增大而增大，随分叉角的增大而减小。分叉处的粘性损失对气泡速度有显著影响。还观察到振荡气泡界面诱导流动再循环并对血管内皮施加高应力的可能性。(C)2010年美国物理学会。[doi：10.1063/1.3442829]
Motivated by a developmental gas embolotherapy technique for selective occlusion of blood flow to tumors, we examined the transport of a pressure-driven semi-infinite bubble through a liquid-filled bifurcating channel. Homogeneity of bubble splitting as the bubble passes through a vessel bifurcation affects the degree to which the vascular network near the tumor can be uniformly occluded. The homogeneity of bubble splitting was found to increase with bubble driving pressure and to decrease with increased bifurcation angle. Viscous losses at the bifurcation were observed to affect the bubble speed significantly. The potential for oscillating bubble interfaces to induce flow recirculation and impart high stresses on the vessel endothelium was also observed. (C) 2010 American Institute of Physics. [doi:10.1063/1.3442829]