Cognition, mood and quality-of-life outcomes among low literacy adults living with epilepsy in rural Kenya: A preliminary study.
Cognition, mood and quality-of-life outcomes among low literacy adults living with epilepsy in rural Kenya: A preliminary study.
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DOI：
10.1016/j.yebeh.2018.05.032
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Abubakar A
中科院分区：
文献类型：
--
作者：
Mwangala PN;Kariuki SM;Nyongesa MK;Mwangi P;Chongwo E;Newton CR;Abubakar A
癫痫通常与神经认知障碍、精神健康和社会心理问题有关，但这些在低收入和中等收入国家很少有记录。本研究的目的是检查肯尼亚基利菲癫痫患者（PWE）的神经认知结果、抑郁症状和社会心理调整。我们评估了这些结果对健康相关生活质量的影响。对63名PWE和83名社区对照组进行自我报告、访谈者管理的抑郁量表（主要抑郁量表）和生活质量（RAND SF-36）测量。神经认知功能采用瑞文标准递进矩阵、数字广度和偶然性命名测试进行评估。结果显示，与对照组相比，PWE组在执行功能、工作记忆、智商、抑郁和生活质量方面得分较低。27例（27%）PWE有抑郁症状，显著高于对照组（6%）； P < 0.001 。有抑郁症状的PWE患者的生活质量评分明显低于无抑郁症状的PWE患者(平均生活质量评分（标准差（SD））： 46.43（13.27）比64.18 (17.69)；P = 0.01。在调整后的线性回归模型中，抑郁影响总体生活质量得分（P = 0.07）以及涉及疼痛（P = 0.04）、嗜睡/疲劳（P = 0.01）和情绪幸福感（P = 0.02）的个人健康指标域。我们的研究结果表明，癫痫与社区心理健康和神经认知障碍的重大负担有关；然而，需要以社区为基础的研究来提供对这些疾病的精确估计。研究成人癫痫（PWE）患者的神经认知结局、抑郁症状和生活质量。27%的PWE和6%的对照组报告有抑郁症状。与对照组相比，PWE组在执行功能、工作记忆、智商和生活质量方面得分较低。有抑郁症状的PWE患者的生活质量评分明显低于无抑郁症状的PWE患者。癫痫加重了基利菲农村地区的精神卫生负担和神经认知障碍。
Epilepsy is frequently associated with neurocognitive impairments, mental health, and psychosocial problems but these are rarely documented in low- and middle-income countries. The aim of this study was to examine the neurocognitive outcomes, depressive symptoms, and psychosocial adjustments of people with epilepsy (PWE) in Kilifi, Kenya. We evaluated the impact of these outcomes on health-related quality of life. Self-report, interviewer-administered measures of depression (Major Depression Inventory) and quality of life (RAND SF-36) were administered to 63 PWE and 83 community controls. Neurocognitive functioning was assessed using Raven's Standard Progressive Matrices, Digit Span, and Contingency Naming Test. The results show that PWE have poorer scores for executive function, working memory, intelligence quotient (IQ), depression, and quality of life than controls. Twenty-seven (27%) of PWE had depressive symptoms, which was significantly greater than in controls (6%); P < 0.001. Quality-of-life scores were significantly lower in PWE with depressive symptoms than in those without depressive symptoms (Mean QoL scores (standard deviation (SD)): 46.43 (13.27) versus 64.18 (17.69); P = 0.01. On adjusted linear regression models, depression affected total quality-of-life scores (P = 0.07) as well as individual health indicator domains touching on pain (P = 0.04), lethargy/fatigue (P = 0.01), and emotional well-being (P = 0.02). Our results show that epilepsy is associated with a significant burden of mental health and neurocognitive impairments in the community; however, community-based studies are needed to provide precise estimates of these disorders. Neurocognitive outcomes, depressive symptoms and quality of life among adults with epilepsy (PWE) were studied. Depressive symptoms were reported in 27% of PWE and in 6% of the controls. PWE had poorer scores for executive function, working memory, IQ and quality of life when compared to controls. Quality of life scores were significantly lower in PWE with depressive symptoms than in those without depressive symptoms. Epilepsy contributes to the burden of mental health and neurocognitive impairments in rural Kilifi.
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DOI：
10.1016/j.yebeh.2012.02.019
发表时间：
2012-05
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Mbuba CK;Abubakar A;Odermatt P;Newton CR;Carter JA
通讯作者：
Carter JA
影响因子：
2.5
作者：
Abubakar A;Van de Vijver F;Van Baar A;Mbonani L;Kalu R;Newton C;Holding P
通讯作者：
Holding P
影响因子：
4.5
作者：
Freeman A;Tyrovolas S;Koyanagi A;Chatterji S;Leonardi M;Ayuso-Mateos JL;Tobiasz-Adamczyk B;Koskinen S;Rummel-Kluge C;Haro JM
通讯作者：
Haro JM
影响因子：
5.6
作者：
LaFrance, W. Curt, Jr.;Baker, Gus A.;Reuber, Markus
通讯作者：
Reuber, Markus
影响因子：
64.3
作者：
Kariuki, Symon M.;Abubakar, Amina;Newton, Charles R. J. C.
通讯作者：
Newton, Charles R. J. C.