A voluntary registry for peanut and tree nut allergy:: Characteristics of the first 5149 registrants
A voluntary registry for peanut and tree nut allergy:: Characteristics of the first 5149 registrants
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DOI：
10.1067/mai.2001.115755
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发表时间：
2001-07-01
影响因子：
14.2
通讯作者：
Sampson, HA
中科院分区：
文献类型：
--
作者：
Sicherer, SH;Furlong, TJ;Sampson, HA
背景资料：1997年建立了一个自愿登记的花生和/或树坚果过敏的个人，以了解更多关于这些食物过敏。目的：本研究的目的是阐明花生和树坚果过敏的各种特征之间的第一个5149登记参与者。方法：通过向食物过敏和过敏反应网络的所有成员和患者分发结构化问卷，建立了该登记研究，过敏症专家家长代理人完成了18岁以下儿童的表格。结果：登记者主要是儿童（89%的登记者年龄小于18岁：中位年龄为5岁），反映了网络的成员资格。3482名登记者（68%）报告了孤立的花生过敏，464名（9%）报告了孤立的树坚果过敏，1203名（23%）报告了对这两种食物过敏。登记者更有可能出生在10月、11月或12月（比值比，1.2; 95%CI，1.18-1.23; P < .0001）。对花生反应的中位年龄为14个月，对坚果反应的中位年龄为36个月;这些分别代表了74%和68%的注册者的首次已知暴露。一半的反应涉及一个以上的器官系统，超过75%的反应需要治疗，通常由医务人员进行治疗。哮喘患者比非哮喘患者更容易出现严重反应（33%比21%; P <0.0001）。与初始反应相比，意外摄入引起的后续反应更为严重。结论：对花生和树坚果的过敏反应通常很严重，通常发生在已知的第一次接触时，并且随着时间的推移会变得更严重。
Background: A voluntary registry of individuals with peanut and/or tree nut allergy was established in 1997 to learn more about these food allergies.Objective: The purpose of this study was to elucidate a variety of features of peanut and tree nut allergy among the first 5149 registry participants.Methods: The registry was established through use of a structured questionnaire distributed to all members of the Food Allergy and Anaphylaxis Network and to patients by allergists. Parental surrogates completed the forms for children under the age of 18 years.Results: Registrants were primarily children (89% of registrants were younger than 18 years of age: the median age was 5 years), reflecting the membership of the Network. Isolated peanut allergy was reported by 3482 registrants (68%), isolated tree nut allergy by 464 (9%), and allergy to both foods by 1203 (23%). Registrants were more likely to have been born in October, November, or December (odds ratio, 1.2; 95% CI, 1.18-1.23; P < .0001). The median age of reaction to peanut was 14 months, and the median age of reaction to tree nuts was 36 months; these represented the first known exposure for 74% and 68% of registrants, respectively. One half of the reactions involved more than 1 organ system, and more than 75% required treatment, frequently from medical personnel. Registrants with asthma were more likely than those without asthma to have severe reactions (33% vs 21%; P < .0001). In comparison with initial reactions, subsequent reactions due to accidental ingestion were more severe. more common outside the home, and more likely to be treated with epinephrine.Conclusions: Allergic reactions to peanut and tree nut are frequently severe, often occur on the first known exposure, and can become more severe over time.