Calcium and vitamin D: skeletal and extraskeletal health.
Calcium and vitamin D: skeletal and extraskeletal health.
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DOI：
10.1007/s11926-008-0020-y
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发表时间：
2008-04-01
影响因子：
5
通讯作者：
Tangpricha, Vin
中科院分区：
文献类型：
--
作者：
Khazai, Natasha;Judd, Suzanne E;Tangpricha, Vin
维生素D因其在钙稳态中的作用而闻名，以获得最佳的骨骼健康。以前认为只有老年人或住院患者才有维生素D不足的风险，但美国普通人群中的许多人25-羟基维生素D（25 D）水平不足。根据第三次全国健康和营养检查调查，61%的白色和91%的美国黑人患有维生素D不足（25 D < 32 ng/mL）。最近的研究表明，至少32 ng/mL的25（OH）D水平是必要的，以最佳保护骨折和肠道吸收的钙。近年来，维生素D被认为对免疫功能、癌症预防和高血压预防等皮肤外功能非常重要。我们回顾了维生素D在骨骼健康中的作用，并介绍了维生素D在其他骨骼外疾病中的数据，特别强调了风湿病患者。
Vitamin D is known for its role in calcium homeostasis for optimal skeletal health. It was previously believed that only elderly or hospitalized patients were at risk for vitamin D insufficiency, but many people in the general US population have insufficient levels of 25-hydroxyvitamin D (25D). According to the Third National Health and Nutrition Examination Survey, 61% of white and 91% of black Americans suffer from vitamin D insufficiency (25D < 32 ng/mL). Recent studies have demonstrated that a minimum 25(OH)D level of 32 ng/mL is necessary for optimal protection from fracture and intestinal absorption of calcium. Recently, vitamin D has been recognized as important for extraskeletal functions such as immune function, cancer prevention, and hypertension prevention. We review the role of vitamin D in skeletal health and present data on vitamin D in other extraskeletal diseases, with special emphasis on the rheumatology patient.