Sarcomatous hepatocellular carcinoma: A special reference to ordinary hepatocellular carcinoma
Sarcomatous hepatocellular carcinoma: A special reference to ordinary hepatocellular carcinoma
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DOI：
10.1046/j.1440-1746.2003.02888.x
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发表时间：
2003-04-01
影响因子：
4.1
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
--
作者：
Nishi, H;Taguchi, K;Tsuneyoshi, M
背景：肉瘤性肝细胞癌（HCC）的预后比普通 HCC 差。肉瘤性肝癌的恶性潜能与细胞增殖或细胞粘附之间的关系尚不清楚。本研究旨在阐明这种关系。方法：在 21 例肉瘤性 HCC 中，包括 16 例手术切除病例和 5 例尸检病例，采用免疫组织化学方法比较每个肉瘤性 HCC 内的肉瘤成分（s-comp）和普通成分（o-comp）。结果：我们发现 o-comp 中 15 例上皮钙粘蛋白（E-cadherin）阳性，9 例阳性。 s-comp 病例（43%）。肉瘤性HCC与普通HCC的E-cadherin阳性肿瘤患病率差异有统计学意义（P < 0.05）。 Ki-67 (MIB1) 标记指数比在 s-comp 中为 127 +/- 40，在 o-comp 中为 80 +/- 33，并且 s-comp 中比 o-comp 中具有更大的增殖能力（P = 0.096）。 结论：本研究表明，E-cadherin 的丢失与肉瘤性 HCC 的形态学改变有关；然而，没有发现与恶性潜力的关系。 (C) 2003 年布莱克威尔出版亚洲有限公司。
Background: Sarcomatous hepatocellular carcinoma (HCC) has a worse prognosis than ordinary HCC. The relationship between the malignant potential of sarcomatous HCC and cell proliferation or cell adhesion is unknown. This study was undertaken to clarify this relationship.Methods: In 21 cases of sarcomatous HCC, including 16 surgically resected and five autopsy cases, immunohistochemistry was used to compare the sarcomatous component (s-comp) and the ordinary component (o-comp) within each sarcomatous HCC.Results: We found 15 epithelial-cadherin (E-cadherin)-positive cases in o-comp (79%) and nine positive cases in s-comp (43%). The difference between sarcomatous HCC and ordinary HCC in E-cadherin-positive tumor prevalence was significant (P < 0.05). The Ki-67 (MIB1) labeling index ratio was 127 +/- 40 in s-comp and 80 +/- 33 in o-comp, and there was a greater tendency to have an ability to multiply in s-comp than in o-comp (P = 0.096).Conclusion: This study indicated that the loss of E-cadherin related to a morphological alteration in sarcomatous HCC; however, no relationship in respect to the malignant potential was found. (C) 2003 Blackwell Publishing Asia Pty Ltd.