Phagocyte-specific S100 proteins:: a novel group of proinflammatory molecules
Phagocyte-specific S100 proteins:: a novel group of proinflammatory molecules
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DOI：
10.1016/s1471-4906(03)00062-0
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发表时间：
2003-04-01
影响因子：
16.8
通讯作者：
Sunderkötter, C
中科院分区：
文献类型：
--
作者：
Roth, J;Vogl, T;Sunderkötter, C
钙结合蛋白S100家族的三个成员组成了一组新的促炎分子，由吞噬细胞释放。由S100A8和S100A9的异常高表达定义的新型炎性综合征证实了最近的体外观察结果，证明了这些蛋白在白细胞募集期间的作用。S100A12通过与晚期糖基化终产物受体相互作用直接激活内皮细胞、单核吞噬细胞和淋巴细胞。因此，这些S100蛋白是调节炎症的有吸引力的靶标。
Three members of the S100 family of calcium-binding proteins comprise a new group of proinflarnmatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.