HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis
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DOI：
10.1038/tpj.2013.40
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发表时间：
2014-06-01
影响因子：
2.8
通讯作者：
Roujeau, J-C
中科院分区：
文献类型：
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作者：
Genin, E.;Chen, D-P;Roujeau, J-C
据报道，HLA-A*31:01与卡马西平（CBZ）诱导的严重皮肤不良反应（SCAR）相关，包括嗜酸性粒细胞增多和全身症状（DRESS）、史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解（TEN）。我们进行了一项国际研究，采用共识诊断标准，共招募了93名来自欧洲或亚洲的CBZ-SCAR患者。我们发现HLA-A*31:01与欧洲人的CBZ-DRESS有显著相关性（P< 0.001），比值比(95%置信区间（CI) = 57.6(11.0-340)），中国人的CBZ-DRESS与HLA-A*31:01有显著相关性（P< 0.001）
HLA-A*31:01 was reported to be associated with carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCAR), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We conducted an international study using consensus diagnosis criteria to enroll a total of 93 patients with CBZ-SCAR from Europe or Asia. We found that HLA-A*31:01 showed a significant association with CBZ-DRESS in Europeans (P< 0.001; odds ratio (OR) (95% confidence interval (CI) = 57.6 (11.0-340)), and the strong association was also found in Chinese (P