High-resolution MRI of deep-seated atherosclerotic arteries using motexafin gadolinium.
High-resolution MRI of deep-seated atherosclerotic arteries using motexafin gadolinium.
复制标题
使用莫泰沙芬钆对深部动脉粥样硬化动脉进行高分辨率 MRI。
DOI：
10.1002/jmri.21174
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Yang,Xiaoming
中科院分区：
文献类型：
--
作者：
Brushett,Chris;Qiu,Bensheng;Atalar,Ergin;Yang,Xiaoming
PurposeTo evaluate the potential of using motexafin gadolinium (MGd) to characterize atherosclerotic plaques of deep‐seated arteries with MRI.Materials and MethodsWe exposed vascular endothelial cells (EC) and smooth muscle cells (SMC) in vitro to varying concentrations of MGd. The fluorescence properties of MGd were then exploited using confocal microscopy to image exposed cells. For an in vivo validation study, we performed surface coil–based and intravascular coil–based high‐resolution MRI of the iliac arteries and the abdominal aorta of three atherosclerotic Yucatan pigs. Subsequently, MGd enhancement of the target vessel walls was quantitatively evaluated and MR images were correlated with histology of the target vessels.ResultsThe in vitro study confirmed the intracellularization of MGd in both cell types and determined the optimum MGd dosage of 0.004 mmol/kg that produced the sufficiently high intracellular fluorescent intensity. The in vivo study showed a steady increase of MGd enhancement to approximately 25% at three hours postinjection of MGd. MRI showed areas of strong enhancement along the lumen boundary, which corresponded to fibrous tissue seen in histology.ConclusionThis study provides initial evidence that MGd may enhance MR vessel wall imaging for the characterization of plaque in deep‐seated arteries. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.
