In vivo 3D imaging of human motor units in upper and lower limb muscles

In vivo 3D imaging of human motor units in upper and lower limb muscles
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人体上肢和下肢肌肉运动单位的体内 3D 成像

DOI:
10.1016/j.clinph.2022.05.018
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发表时间:
2022
影响因子:
4.7
通讯作者:
Heskamp L
Heskamp L
中科院分区:
医学3区
文献类型:
--
作者:
Heskamp L

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目的应用磁共振成像(MRI)对人体手部、前臂和小腿肌肉运动单位的横断面和三维形态进行评价。方法采用磁共振弥散加权成像技术,对健康对照组小腿、前臂和手部肌肉单层运动单位(n=6)和小腿多层运动单位(n=7)进行三维成像。结果运动单位横截面积(CSA)和最大FERET直径(FDmax)小腿之间无差异(CSA:22.4%±2.4%;FDmax:22.4%±8.4%;FDmax:22.4%±8.4%);前臂(CsA:23.6±14.1nmm2;FDmax:9.0±13.3 mm)和手部(CsA:26.8±12.8 mm,FDmax:9.6±22.7 mm)(方差分析,p=0.487和p=0.587)。小腿运动单位长8.0±33.8 cm,运动单位中段CSA最大。结论运动单元磁共振成像(MUMRI)可应用于上肢肌肉,并能活体显示人体运动单元的三维结构。3D成像显示了一个比之前想象的更复杂的人体运动单位结构。
ObjectiveTo assessin-vivocross-sectional and 3D morphology of human motor units in hand, forearm and lower leg muscles using magnetic resonance imaging (MRI).MethodsDiffusion weighted MRI was used with in-scanner electrical stimulation in healthy controls to image motor units at a single slice in lower leg, forearm and hand muscles (n = 6) and multiple slices in the lower leg for 3D assessment (n = 7).ResultsMotor unit cross-sectional area (CSA) and maximum Feret diameter (FDmax) did not differ between the lower leg (CSA: 22.4 ± 8.4 mm2; FDmax: 8.7 ± 2.4 mm), forearm (CSA: 23.6 ± 14.1 mm2; FDmax: 9.0 ± 3.3 mm) and hand (CSA: 26.8 ± 12.8 mm2and FDmax: 9.6 ± 2.7 mm) (ANOVA;p= 0.487 andp= 0.587, respectively). Lower leg motor units were 8.0 ± 3.8 cm long with largest CSA in the motor unit’s middle section. 3D motor unit imaging revealed a complex structure with several units splitting and re-forming along their length.ConclusionsMotor unit MRI (MUMRI) can be applied to upper limb muscles, and can reveal the 3D structure of human motor unitsin-vivo.SignificanceMUMRI provides the firstin-vivo2D images of upper limb motor units and 3D images of lower leg motor units. 3D imaging suggest a more complex human motor unit structure than previously thought.
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