A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
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DOI：
10.1089/aid.2007.0065
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发表时间：
2007-10-01
影响因子：
1.5
通讯作者：
McClelland, R. Scott
中科院分区：
文献类型：
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作者：
Graham, Susan M.;Baeten, Jared M.;McClelland, R. Scott
我们调查了78名肯尼亚妇女的白蛋白水平和HIV-1疾病进展之间的关系，这些妇女从感染前到中位70个月。随着HIV-1感染，中位白蛋白从38.5 g/L降至36.8 g/L（p = 0.07），低白蛋白血症的患病率从16%增至32%（p = 0.02）。HIV-1感染时白蛋白每减少1 g/L，进展为CD 4计数的风险增加13%（p = 0.01）。
We investigated the association between albumin levels and HIV-1 disease progression among 78 Kenyan women followed from before infection through a median of 70 months. With HIV-1 acquisition, median albumin decreased from 38.5 g/liter to 36.8 g/liter (p = 0.07) and the prevalence of hypoalbuminemia increased from 16% to 32% (p = 0.02). Each 1 g/liter decrease in albumin with HIV-1 acquisition was associated with a 13% increase (p = 0.01) in the risk of progressing to a CD4 count