Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks
Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks
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DOI：
10.1016/j.jneumeth.2004.10.005
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发表时间：
2005-05-15
影响因子：
3
通讯作者：
Bain, PG
中科院分区：
文献类型：
--
作者：
Liu, XG;Carroll, CB;Bain, PG
在这项研究中，我们使用数字化螺旋绘制任务量化帕金森病（PD）患者手臂中药物诱导的运动障碍的严重程度。设计了两个螺旋图，即圆形和方形螺旋，分别表示连续和离散的臂运动，并确定了螺旋的大小，以便涉及远端和近端臂关节。15名平均病程为14.4 ± 7.4年的PD患者在左旋多巴激发后30分钟进行评估，同时进行圆形和方形螺旋绘制任务。计算绘画运动的速度，并测量不自主运动障碍运动的幅度作为绘画速度的标准差（SD-DV）。运动障碍运动的平均幅度进行了比较武器和任务，并与临床措施，包括贝恩运动障碍量表和总的统一帕金森氏病评定量表（CAFRS）评分。结果表明，在该组PD患者中，手臂之间或连续（圆形）和离散（方形）螺旋绘图之间的运动障碍幅度无统计学显著差异，但有趣的是，手臂和绘图模式之间的相互作用是显着的。从螺旋绘图任务测量的运动障碍的幅度之间的显着相关性被发现和“开”或“关”的运动障碍量表和贝恩运动障碍量表。我们的结论是，绘图任务可以用来提供一个客观的方法来量化药物引起的运动障碍的严重程度在PD患者的手臂。© 2004 Elsevier B. V.保留所有权利。
In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are designed to, respectively, represent the continuous and discrete arm motions, and the size of the spiral is decided so that both the distal and proximal arm joints are involved. Fifteen PD patients, average disease duration 14.4 ± 7.4 years, were assessed 30 min after a levodopa challenge whilst performing circular and square spiral-drawing tasks. The velocity of drawing movements was computed and the amplitude of the involuntary dyskinetic movements was measured as the standard deviation of the drawing velocity (SD-DV). The mean amplitude of dyskinetic movements was compared between arms and tasks and was correlated with clinical measures including the Bain dyskinesia scale and the total unified Parkinson's disease rating scale (UPDRS) score. The results showed that there was no statistically significant difference in the amplitude of dyskinesias either between the arms or between the continuous (circular) and discrete (square) spiral drawings in this group of PD patients, but interestingly the interaction between arm and drawing pattern was significant. Significant correlations were found between the magnitude of dyskinesia measured from the spiral-drawing tasks and both the 'on' or 'off' UPDRS and also the Bain dyskinesia scale. We conclude that the drawing tasks may be used to provide an objective method of quantifying the severity of drug-induced dyskinesias in the arm in PD patients. © 2004 Elsevier B.V. All rights reserved.